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Although soy protein (SP) adhesives have shown great potential in promoting the green and sustainable development of the wood industry, the practical application of SP adhesives is limited by poor performance (bonging strength, mold resistance and water resistance). Cross-linking modification is considered to be the most effective modification method for SP adhesives. In this work, non-antibacterial l-tyrosine (TYR) was treated with epichlorohydrin to graft multiple epoxy groups and transformed into tetraepoxy l-tyrosine (ETY). Interestingly, ETY exhibited obvious antifungal properties with a bacteriostatic rate as high as 98.3%. Adding a low amount (3 wt%) of ETY, the wet shear strength of the modified adhesive was 169.1% higher than that of the pristine SP adhesive, reaching 1.83 MPa. Moreover, in an environment of 28 °C and 80% humidity, both uncured and cured SP adhesives (with 3 wt% ETY) exhibited an …