作者
Alejandro Campos, Lizeth Cifuentes, Anas Hashem, Bradley Busebee, Maria D Hurtado-Andrade, Maria L Ricardo-Silgado, Alison McRae, Alan De la Rosa, Fauzi Feris, Joshua T Bublitz, Donald Hensrud, Michael Camilleri, Todd A Kellogg, Jeanette E Eckel-Passow, Janet Olson, Andres Acosta
发表日期
2022/8
期刊
Obesity surgery
卷号
32
期号
8
页码范围
2632-2640
出版商
Springer US
简介
Introduction
Heterozygous variants in the leptin-melanocortin pathway are associated with obesity. However, their effect on the long-term outcomes after Roux-en-Y gastric bypass (RYGB) is still unknown.
Methods
In this matched case–control study, 701 participants from the Mayo Clinic Biobank with a history of RYGB were genotyped. Sixty-three patients had a heterozygous variant in the leptin-melanocortin pathway. After excluding patients with potential confounders, carriers were randomly matched (on sex, age, body mass index [BMI], and years since surgery) with two non-carrier controls. The electronic medical record of carriers and matched non-carriers was reviewed for up to 15 years after RYGB.
Results
A total of 50 carriers and 100 matched non-carriers with a history of RYGB were included in the study. Seven different genes (LEPR, PCSK1, POMC, SH2B1, SRC1, MC4R, and SIM1) in the leptin-melanocortin …
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A Campos, L Cifuentes, A Hashem, B Busebee… - Obesity surgery, 2022
