作者
Stefan Hohaus, Manuela Giachelia, Giuseppina Massini, G Mansueto, Barbara Vannata, Valentina Bozzoli, Marianna Criscuolo, Francesco D'Alò, Maurizio Martini, Luigi Maria Larocca, Maria Teresa Voso, Giuseppe Leone
发表日期
2009/8/1
期刊
Annals of oncology
卷号
20
期号
8
页码范围
1408-1413
出版商
Elsevier
简介
Background
Levels of cell-free circulating DNA have been correlated to clinical characteristics and prognosis in patients with cancers of epithelial origin, while there are no data on patients with B-lymphoproliferative diseases.
Patients and methods
Cell-free DNA levels in the plasma samples of 142 patients with lymphomas [45 with Hodgkin's lymphoma (HL), 63 with diffuse large B-cell non-Hodgkin's lymphoma (DLBCL), 24 with follicular, and 10 with mantle cell non-Hodgkin's lymphoma (NHL)] at diagnosis and of 41 healthy individuals were determined using a quantitative PCR for the β-globin gene.
Results
Levels of circulating DNA in patients with HL, DLBCL, and mantle cell NHL were significantly higher than in controls (P < 0.01 for all). Increased levels of plasma DNA were associated with advanced stage disease, presence of B-symptoms, elevated lactate dehydrogenase levels, and age >60 years (P = 0.009; <0 …
引用总数
学术搜索中的文章
S Hohaus, M Giachelia, G Massini, G Mansueto… - Annals of oncology, 2009