作者
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai Masahiro 2, Manuscript analyses team leader, Manuscript analyses team member: meta-analysis Mehtonen Juha 1, Manuscript analyses team member: heritability, methods and supplements, Manuscript analyses team member: PHEWAS, Manuscript analyses team member: Mendelian randomization, Manuscript analyses team member: PC projection and gene prioritization, Manuscript analyses team member: gene prioritization Finucane Hilary 3 29, Manuscript analyses team member: sensitivity analysis Cordioli Mattia 1, Manuscript analyses team members: PC projection Martin Alicia R. 3 29 Zhou Wei 3 29, In silico analysis team members Pasaniuc Bogdan 32 Julienne Hanna 33 Aschard Hugues 33 Shi Huwenbo 34 Yengo Loic 35 Polimanti Renato 6 Ghoussaini Maya 15 38 Schwartzentruber Jeremy 15 38 Dunham Ian 15 40, Project management leader, Project management support Chwialkowska Karolina 42 Francescatto Margherita 43 Trankiem Amy 2 Balaconis Mary K. 2, Lea Davis, Sulggi Lee, James Priest, Alessandra Renieri, Vijay G Sankaran, David van Heel, Patrick Deelen, J Brent Richards, Tomoko Nakanishi, Les Biesecker, V Eric Kerchberger, J Kenneth Baillie, Francesca Mari, Anna Bernasconi, Stefano Ceri Baillie, Arif Canakoglu, Scientific communication leaders Wolford Brooke 68, Scientific communication members Faucon Annika 69 Dutta Atanu Kumar 70 Schurmann Claudia 71 Harry Emi 72 Birney Ewan 73 Nguyen Huy 2 Nasir Jamal 74 Kaunisto Mari 1 Solomonson Matthew 2 Dueker Nicole 76 Vadgama Nirmal 46 Limou Sophie 78, Website development leaders, Analysis team leader Auton Adam 130, Data collection leaders 23andMe COVID-19 Team*, Janie F Shelton, Anjali J Shastri, Teresa Filshtein-Sonmez, Daniella Coker, Antony Symons, Jorge Esparza-Gordillo, Stella Aslibekyan, Jared O’Connell, Chelsea Ye, Catherine H Weldon, Analysis team leader Perera Minoli 132, Data collection leaders O’Leary Kevin 133 Tuck Matthew 134 O’Brien Travis 135 Meltzer David 136 O’Donnell Peter 137 Nutescu Edith 138, Analysis team members Yang Guang 132, Data collection members Alarcon Cristina 132 Herrmann Stefanie 132 Mazurek Sophia 133 Banagan Jeff 134 Hamidi Zacharia 134 Barbour April 144 Raffat Noora 136 Moreno Diana 138, Admin team member Friedman Paula 132, Analysis team leader Ferwerda Bart 148, Data collection leaders van de Beek Diederik 148 Brouwer Matthijs C. 148 Vlaar Alexander PJ 149 Wiersinga W. Joost 150, Analysis team members Posthuma Danielle 16 Tissink Elleke 16 Koos Zwinderman AH 151 Uffelmann Emil 16, Analysis team leader Roberts Genevieve 162, Data collection leader Park Danny 162, Admin team leader Ball Catherine A. 162, Analysis team members Coignet Marie 162 McCurdy Shannon 162 Knight Spencer 162 Partha Raghavendran 162 Rhead Brooke 162, Data collection members Zhang Miao 162 Berkowitz Nathan 162 Gaddis Michael 162 Noto Keith 162 Ruiz Luong 162 Pavlovic Milos 162, Admin team members Hong Eurie L. 162 Rand Kristin 162 Girshick Ahna 162 Guturu Harendra 162 Baltzell Asher Haug 162, Analysis team leader, Data collection leaders Rahmouni Souad 163 Guntz Julien 164, Admin team leader Beguin Yves 165, Analysis team members Pigazzini Sara 1 Nkambule Lindokuhle 3 29 167, Analysis team leader, Data collection leader Morrison David R. 17, Admin team leaders Mooser Vincent 56 174, Analysis team members Forgetta Vincenzo 17 Li Rui 56 174, Admin team members Schurr Erwin 184 Lepage Pierre 56 174 Ragoussis Jiannis 56 174 Auld Daniel 56 174 Chassé Michaël 183 185 Kaufmann Daniel E. 183 186 Lathrop G. Mark 56 174 Adra Darin 17, Analysis team leaders Davis Lea K. 187 188 Cox Nancy J. 187 188 Below Jennifer E. 187 188, Analysis team members Sealock Julia M. 187 188 Faucon Annika B. 187 188 Shuey Megan M. 187 188 Polikowsky Hannah G. 187 188 Petty Lauren E. 187 188 Shaw Douglas M. 187 188 Chen Hung-Hsin 187 188 Zhu Wanying 187 188, Data collection leader Ludwig Kerstin U. 189, Analysis team members Schröder Julia 189 Maj Carlo 190, Analysis team leader Fuchsberger Christian 209, Data collection leaders Pattaro Cristian 209 De Grandi Alessandro 209, Admin team leader Pramstaller Peter 209, Analysis team members Emmert David 209 Melotti Roberto 209 Foco Luisa 209, Admin team members Mascalzoni Deborah 209 Gögele Martin 209 Domingues Francisco 209 Hicks Andrew 209, Analysis team leader Gignoux Christopher R. 210, Data collection leaders Wicks Stephen J. 210 Crooks Kristy 210, Admin team leader Barnes Kathleen C. 210, Analysis team members Daya Michelle 210 Shortt Jonathan 210 Rafaels Nicholas 210 Chavan Sameer 210, Analysis team leaders Goldstein David B. 211 Kiryluk Krzysztof 212, Data collection leaders Sengupta Soumitra 213 Chung Wendy 214 Reilly Muredach P. 215, Analysis team members Khan Atlas 215 Wang Chen 215 Povysil Gundula 216 Bhardwaj Nitin 216 Gharavi Ali G. 215 Ionita-Laza Iuliana 217, Data collection members Shang Ning 215 O’Byrne Sheila M. 215 Nandakumar Renu 215 Menon Amritha 213 So Yat S. 213 Hod Eldad 218, Admin team member Pendrick Danielle 218, Analysis team leader Kim Han-Na 219 220, Data collection leaders Park Soo-Kyung 221 Kim Hyung-Lae 222 Kang Chang Kyung 223 Lee Hyo-Jung 224 Song Kyoung-Ho 225, Admin team leaders Jae Yoon Kyung 226 227 228 Paik Nam-Jong 229 230, Analysis team members Seok Woojin 231 Yoon Heejun 232, Data collection members Joo Eun-Jeong 233 Chang Yoosoo 234 235 Ryu Seungho 234 235 Park Wan Beom 223 Su Park Jeong 236 Un Park Kyoung 236 Ham Sin Young 225 Jung Jongtak 225 Kim Eu Suk 225 Kim Hong Bin 225, Analysis team leaders Ellinghaus David 237 238 Degenhardt Frauke 237 Cáceres Mario 239 240 Juzenas Simonas 237 Lenz Tobias L. 241 242, Admin team leaders Franke Andre 237 267 Hov Johannes R. 254 268 269 270 Karlsen Tom H. 254 268 269 270 Folseraas Trine 254 268 269 270 Maya-Miles Douglas 1244 1245 244, Oliver A Cornely, Orazio Palmieri, Paolo Tentorio, Pedro M Rodrigues, Pedro P España, Per Hoffmann, Petra Bacher, Phillip Suwalski, Raúl de Pablo, Rosa Nieto, Salvatore Badalamenti, Sandra Ciesek, Sara Bombace, Sibylle Wilfling, Søren Brunak, Stefanie Heilmann-Heimbach, Humanitas COVID-19 Task Force*, Humanitas Gavazzeni COVID-19 Task Force*, Stephan Ripke, Thomas Bahmer, Ulf Landmesser, Ulrike Protzer, Valeria Rimoldi, Vegard Skogen, Victor Andrade, Victor Moreno, Wolfgang Poller, Xavier Farre, Xiaomin Wang, Yascha Khodamoradi, Zehra Karadeniz, Adolfo de Salazar, Adriana Palom, Alba-Estela Garcia-Fernandez, Albert Blanco-Grau, Alberto Zanella, Alessandra Bandera, Almut Nebel, Andrea Biondi, Andrea Caballero-Garralda, Andrea Gori, Andreas Lind, Anna Ludovica Fracanzani, Anna Peschuck, Antonio Pesenti, Carmen de la Horra, Chiara Milani, Cinzia Paccapelo
发表日期
2021/12/16
期刊
Nature
卷号
600
期号
7889
页码范围
472-477
出版商
Nature Publishing Group UK
简介
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19,, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19 …
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