作者
Wissam Ghusn, Sima Fansa, Diego Anazco, Elif Tama, Bryan Nicolalde, Khushboo Gala, Lizeth Cifuentes, Alan De La Rosa, Daniel Sacoto, Alejandro Campos, Fauzi Feris, Andres Acosta
发表日期
2023/10/1
期刊
Official journal of the American College of Gastroenterology| ACG
卷号
118
期号
10S
页码范围
S1127-S1128
出版商
LWW
简介
Methods:
We performed a multi-centered cohort study of patients with NAFLD and BMI≥ 27 kg/m 2 taking semaglutide for weight loss. Patients with history of bariatric surgery, taking other anti-obesity medications, and with active malignancy or pregnancy were excluded from this study. Our primary outcome included assessing the change in LFTs and secondary outcomes included evaluating total body weight loss percentage (TBWL%). We performed a paired t-test for our primary and secondary outcomes. Data are presented as mean±standard deviation (SD).
Results:
WWe identified 40 patients (59% female, mean age 48.7±11.8 years, BMI 40.1±8.9 kg/m 2) with NAFLD and taking semaglutide (Table 1). In our study, there was a significant decrease in alanine transferase (ALT) from 73 mg/dl at baseline to 45 mg/dl at 12 months with a mean difference of 28 mg/dl (n= 32; 95% CI 9.8 to 45.3; P= 0.004; Figure 1A …
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