作者
Siddharth Singh, Sudhakar K Venkatesh, Zhen Wang, Frank H Miller, Utaroh Motosugi, Russell N Low, Tarek Hassanein, Patrick Asbach, Edmund M Godfrey, Meng Yin, Jun Chen, Andrew P Keaveny, Mellena Bridges, Anneloes Bohte, Mohammad Hassan Murad, David J Lomas, Jayant A Talwalkar, Richard L Ehman
发表日期
2015/3/1
来源
Clinical Gastroenterology and Hepatology
卷号
13
期号
3
页码范围
440-451. e6
出版商
WB Saunders
简介
Background & Aims
Magnetic resonance elastography (MRE) is a noninvasive tool for staging liver fibrosis. We conducted a meta-analysis of individual participant data collected from published studies to assess the diagnostic accuracy of MRE for staging liver fibrosis in patients with chronic liver diseases (CLD).
Methods
Through a systematic literature search of multiple databases (2003–2013), we identified studies on diagnostic performance of MRE for staging liver fibrosis in patients with CLD with native anatomy, using liver biopsy as the standard. We contacted study authors to collect data on each participant’s age, sex, body mass index (BMI), liver stiffness (measured by MRE), fibrosis stage, staging system used, degree of inflammation, etiology of CLD, and interval between MRE and biopsy. Through a pooled analysis, we calculated cluster-adjusted area under the receiver-operating curve, sensitivity, and …
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