作者
Willem J Lammers, Henk R van Buuren, Gideon M Hirschfield, Harry LA Janssen, Pietro Invernizzi, Andrew L Mason, Cyriel Y Ponsioen, Annarosa Floreani, Christophe Corpechot, Marlyn J Mayo, Pier M Battezzati, Albert Parés, Frederik Nevens, Andrew K Burroughs, Kris V Kowdley, Palak J Trivedi, Teru Kumagi, Angela Cheung, Ana Lleo, Mohamad H Imam, Kirsten Boonstra, Nora Cazzagon, Irene Franceschet, Raoul Poupon, Llorenç Caballeria, Giulia Pieri, Pushpjeet S Kanwar, Keith D Lindor, Bettina E Hansen, Global PBC Study Group
发表日期
2014/12/1
期刊
Gastroenterology
卷号
147
期号
6
页码范围
1338-1349. e5
出版商
WB Saunders
简介
Background & Aims
Noninvasive surrogate end points of long-term outcomes of patients with primary biliary cirrhosis (PBC) are needed to monitor disease progression and evaluate potential treatments. We performed a meta-analysis of individual patient data from cohort studies to evaluate whether patients’ levels of alkaline phosphatase and bilirubin correlate with their outcomes and can be used as surrogate end points.
Methods
We performed a meta-analysis of data from 4845 patients included in 15 North American and European long-term follow-up cohort studies. Levels of alkaline phosphatase and bilirubin were analyzed in different settings and subpopulations at different time points relative to the clinical end point (liver transplantation or death).
Results
Of the 4845 patients, 1118 reached a clinical end point. The median follow-up period was 7.3 years; 77% survived for 10 years after study enrollment. Levels of …
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