… CYP2D6 genotyping revealed that the infant’s mother was … in pain management include
amitriptyline and imipramine (… demonstrated effectiveness in the treatment of diabetic neuropathy…

… active effects of the drug resulting potentially in increased efficacy but … CYP2D6 and CYP2C19
defective variants and increased risk of side effects in patients treated with amitriptyline [96…

… physiologic effects of the medication in the body (ie, efficacy, … effects: some studies find patients
with the rs6311 genotype C/C … amitriptyline and nortriptyline are hydroxylated by CYP2D6 …

… (nortriptyline and amitriptyline) and anticonvulsants (… For instance, the CYP2D6 genotype
was reported by Nasare … association study for the efficacy of drugs for the treatment of …

… is associated with a lower clearance of amitriptyline (Figure 7) , … the impact of the SERTPR
genotype on the efficacy and safety of … CYP2D6 genotype had no impact on the safety and …

… detrimental effect of the S allele on antidepressant efficacy … The most replicated association
was between CYP2D6 … only in patients treated with P-gp substrates (amitriptyline, citalopram, …

… The candidate carried out genotyping and haplotyping (~60 … In order to predict the clinical
utility of CYP2D6 and CYP2C19 … SNP exerting their effects through unknown mechanisms …

… citalopram [Citation64], and amitriptyline [Citation65]. CYP3A … , PMs CYP2D6 genotype
predicted the risk of adverse effects … in drug metabolism, therapeutic efficacy, and drug-induced …

… Other factors to consider when judging clinical significance include how quickly the drug
takes effect, tolerability, and the drug's influence on other efficacy end points such as function …

… This open-label pilot study is aimed to evaluate the efficacy … 30 patients with oxaliplatin-induced
peripheral neuropathy … in our study was consistent with its effect in the treatment of DPNP…