… detect because the lack of efficacy can be explained by other … A correlation between CYP2D6
genotype and the metabolic … SSRIs, old TCAs like amitriptyline remain on the drug market …

… In the present studies, the effect of CYP2D6 and CYP3A … and long-term consequences
and effectiveness are not therefore … Amitriptyline is a tricyclic antidepressant that is currently …

… , even if the patient was genotyped for CYP2D6 and was known to … The effects can be
profound toxicity or reduced efficacy of drugs … Where this study is to be considered as a pilot study …

… the clinical impact of CYP2D6 genotype in children. There are … Both amitriptyline and the
secondary amine metabolites are … the impact of CYP2D6 variability on the efficacy and adverse …

… 2017 has seen Pharmacogenomics publish novel, high-impact … a pilot study of the effect of
CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic peripheral neuropathy …

… its efficacy and cost effectiveness in optimising therapeutic … drugs (eg a number of CYP2D6
substrates). Furthermore, … as well as diazepam, propranolol and amitriptyline.[57] For example…

… the annual cost of treating patients at extremes for CYP2D6 activity (… [48,50] The antidepressant
amitriptyline can penetrate the … Moreover, the effects of drugs with established efficacy on …

… Opioid effectiveness in treating neuropathic pain is poorly … of fewer anticholinergic side
effects. Tricyclic antidepressants block … It is O-demethylated by CYP2D6 to desvenlafaxine that is …

… —The metabolism of the tricyclic anti-depressants amitriptyline, … strongly indicates that
genotyping can improve efficacy, … Extension of a pilot study: impact of the cytochrome P450 2D6 …

… , MS Impact of CYP2D6 genotype on amitriptyline efficacy for the treatment of diabetic
peripheral neuropathy: A pilot study. Pharmacogenomics 2017, 18, 433–443.[CrossRef] 55. …