Personalized sequencing and the future of medicine: discovery, diagnosis and defeat of disease

ED Esplin, L Oei, MP Snyder - Pharmacogenomics, 2014 - Taylor & Francis
… , which is central to treatment efficacy. Germline patient … While these pilot studies were
performed in ostensibly healthy … , such as amitriptyline and nortriptyline [Citation88]. The …

[HTML][HTML] Histological, immunohistochemical and radiographic evaluation of Amitriptyline administration on the periodontium of albino rats (An experimental study)

R Hassan, NF Ahmed, SI Hussein - The Saudi Dental Journal, 2022 - Elsevier
… data, this study aimed to appraise the effect of Amitriptyline on albino rat … Amitriptyline
was the drug of choice in this study because it is widely used TCA and has same efficacy as …

Gender, genetics, and analgesia: understanding the differences in response to pain relief

S Packiasabapathy, S Sadhasivam - Journal of pain research, 2018 - Taylor & Francis
effect profile of the opioid, rather than the analgesic efficacy … based on CYP2D6 genotype,
which will be discussed later. … Citation80 Tricyclic antidepressants such as amitriptyline are …

Pharmacogenomics: challenges and opportunities in therapeutic implementation

YWF Lam, SR Scott - 2018 - books.google.com
… Drug metabolism and transporter genotypes can affect drug … in which genotyping to determine
clopidogrel effectiveness is … the adoption of CYP2D6 genotyping in the therapeutic use of …

[PDF][PDF] Blood loss after cardiopulmonary bypass, standard vs titrated protamine: A meta-analysis

J Wang, HP Ma, H Zheng - Neth J Med, 2013 - njmonline.nl
… to further explore the effectiveness of the Hemochron system … Background: Peripheral
neuropathy is a frequent side effect … data on CYP450 and HLA genotypes relevant to those 100 …

Tricyclic Antidepressant Drug Interactions

JP Walterscheid, TJ Danielson - Handbook of Drug Interactions: A Clinical …, 2012 - Springer
… Antidepressant treatment efficacy is greatest when the … prescription drug effects on the
metabolism of amitriptyline and … Two additional studies examined the impact of CYP2D6 genotype

Antiemetic therapy for gastroparesis

JM Wo, RW McCallum, Z Gonzalez - Gastroparesis, 2021 - Elsevier
… the CYP2D6 allele genotypes with variability in drug efficacy in … RCT trial of patients with
functional dyspepsia, amitriptyline, … randomized pilot study evaluating EA in 19 diabetic patients …

Genetic predisposition to adverse drug reactions in the intensive care unit

PE Empey - Critical care medicine, 2010 - journals.lww.com
CYP2D6 genotype or metabolizer status and clinical effect … prone to experience the side
effect of peripheral neuropathy ( 17 ). … can decrease warfarin ADRs and the cost-effectiveness of …

Precision medicine in neuropathic pain

J Sachau, R Baron - Precision Medicine, 2023 - Springer
… inhibition capacity, predicted better drug efficacy (defined as overall effect of the drug on pain).
… -blind, parallel-group study in patients with diabetic peripheral neuropathic pain. Pain 154:…

Emerging strategies for the treatment of gastroparesis

J Langworthy, HP Parkman, R Schey - Expert review of …, 2016 - Taylor & Francis
… There are currently no studies comparing the efficacy of these … Amitriptyline and Nortriptyline
have been shown to improve … pilot study of BH4 supplementation in humans with diabetic