High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units
… into tablets at amorphous solid dispersion loadings up to 89 wt… amorphous dispersion during
drying by TFE. Pharmacokinetic performance of the TFE-isolated, co-precipitated dispersion …
drying by TFE. Pharmacokinetic performance of the TFE-isolated, co-precipitated dispersion …
Formulation and process design for a solid dosage form containing a spray-dried amorphous dispersion of ibipinabant
MM Leane, W Sinclair, F Qian, R Haddadin… - Pharmaceutical …, 2013 - Taylor & Francis
… the solid dispersion may stabilise the amorphous form, … between excipients and the
amorphous dispersion. In addition, … on the way to a coated solid dosage form, are all known risk …
amorphous dispersion. In addition, … on the way to a coated solid dosage form, are all known risk …
Amorphous solid dispersions and nano-crystal technologies for poorly water-soluble drug delivery
C Brough, RO Williams Iii - International journal of pharmaceutics, 2013 - Elsevier
… as a solid amorphous dispersion utilizing HME technology. … that reduced the number of
dosage units and eliminated the … solid oral dosage form based on amorphous solid dispersion …
dosage units and eliminated the … solid oral dosage form based on amorphous solid dispersion …
Manufacturing strategies to develop amorphous solid dispersions: An overview
… the thermodynamic behavior of amorphous SDs that have not … used in polymeric amorphous
solid dispersion systems (PASDs) … release pattern from the dosage form since the improper …
solid dispersion systems (PASDs) … release pattern from the dosage form since the improper …
Amorphous solid dispersions (ASDs): The influence of material properties, manufacturing processes and analytical technologies in drug product development
R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
… drugs into an amorphous solid dispersion (ASD) … amorphous forms are thermodynamically
unstable, the materials and technologies that enable ASD formation, the subsequent dosage …
unstable, the materials and technologies that enable ASD formation, the subsequent dosage …
Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations
… factor of the formulation), a dispersed amorphous API with a 100 mg dose and a drug
content of 20% suggests that only the mass of the dispersion is 500 mg. The literature suggests …
content of 20% suggests that only the mass of the dispersion is 500 mg. The literature suggests …
Effects of the preparation process on the properties of amorphous solid dispersions
S Huang, RO Williams - Aaps Pharmscitech, 2018 - Springer
… for generating amorphous solid dispersions have been well … However, the amorphous solid
dispersions manufactured by … those properties of amorphous solid dispersions. For example, …
dispersions manufactured by … those properties of amorphous solid dispersions. For example, …
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at …
… Importantly, this approach appears to offer another route to further increase the drug load
in final dosage units and is significant as increased drug loading generally results in slower or …
in final dosage units and is significant as increased drug loading generally results in slower or …
Amorphous solid dispersions: An update for preparation, characterization, mechanism on bioavailability, stability, regulatory considerations and marketed products
… to be processed into tablet or capsule dosage form. The biggest task of a solid dispersion is
to maintain the drug in the amorphous state in the final dosage form. This can be attained by …
to maintain the drug in the amorphous state in the final dosage form. This can be attained by …
Amorphous solid dispersions: Rational selection of a manufacturing process
… originates amorphous solid dispersions and uses polymeric carriers. The third generation
comprises amorphous solid dispersion composed by a combination of amorphous carriers …
comprises amorphous solid dispersion composed by a combination of amorphous carriers …