Downstream processing of a ternary amorphous solid dispersion: The impacts of spray drying and hot melt extrusion on powder flow, compression and dissolution

MT Davis, CB Potter, GM Walker - International journal of pharmaceutics, 2018 - Elsevier
… of amorphous itraconazole exhibiting enhanced dissolution properties were studied. Preparation
of this ternary amorphous solid dispersion … a 100 mg dose of amorphous itraconazole. …

Pharmaceutical applications of solid dispersion systems

WL Chiou, S Riegelman - Journal of pharmaceutical sciences, 1971 - Elsevier
… Obi (17) to prepare fast-release solid dispersion dosage forms. The physical mixture of a drug
and … inability to differentiate amorphous precipitation from molecular dispersion if the lattice …

[HTML][HTML] Effect of spray-dried particle morphology on mechanical and flow properties of felodipine in PVP VA amorphous solid dispersions

A Ekdahl, D Mudie, D Malewski, G Amidon… - Journal of …, 2019 - Elsevier
Amorphous solid dispersions (ASDs) are commonly used to enhance the oral absorption of
drugs with solubility or dissolution rate limitations. Although the ASD formulation is typically …

[HTML][HTML] … formulation strategies to generate supersaturated solutions of delamanid: in situ salt formation during amorphous solid dispersion fabrication for more robust …

T Van Duong, HT Nguyen, LS Taylor - European Journal of Pharmaceutics …, 2022 - Elsevier
… Despite a fairly long half-life, DLM requires twice daily dosing and must be taken … amorphous
stability and enhance the release of delamanid by developing amorphous solid dispersions

Improved release of celecoxib from high drug loading amorphous solid dispersions formulated with polyacrylic acid and cellulose derivatives

T Xie, LS Taylor - Molecular pharmaceutics, 2016 - ACS Publications
… for drug controlled release from amorphous solid dispersions at moderate to high drug …
release rates, result in large or even multiple dosage units, which is undesirable from a patient …

Aqueous dissolution and dispersion behavior of polyvinylpyrrolidone vinyl acetate-based amorphous solid dispersion of ritonavir prepared by hot-melt extrusion with …

N Siriwannakij, T Heimbach, ATM Serajuddin - Journal of Pharmaceutical …, 2021 - Elsevier
… drug release from ASD is that once the water-soluble carrier starts dissolving from near
the surface, the liberated water-insoluble drug coats the surface of particles or dosage units, …

Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture

ACF Rumondor, LS Taylor - Molecular pharmaceutics, 2010 - ACS Publications
… , reducing the performance benefit of the dosage form. To inhibit drug … amorphous solid
dispersion. Due to its hygroscopic nature, the addition of the polymer to form a solid dispersion

[HTML][HTML] Cellulose based polymers in development of amorphous solid dispersions

RB Chavan, S Rathi, VGSS Jyothi… - Asian journal of …, 2019 - Elsevier
amorphous solid dispersion owing to their diverse physicochemical properties. More than 20
amorphous solid dispersion-… in generation of amorphous solid dispersions. These polymers …

Refining stability and dissolution rate of amorphous drug formulations

H Grohganz, PA Priemel, K Löbmann… - Expert opinion on …, 2014 - Taylor & Francis
… solid dispersions is the most established technique for the stabilisation of amorphous forms,
dosing to rats) compared with amorphous and crystalline furosemide acid. Importantly, the …

Amorphous drug-PVP dispersions: application of theoretical, thermal and spectroscopic analytical techniques to the study of a molecule with intermolecular bonds in …

M Tobyn, J Brown, AB Dennis, M Fakes… - Journal of …, 2009 - Elsevier
… as intermolecular bonds in the crystalline and pure amorphous drug system. The Gordon-…
in an amorphous dispersion, may underestimate the likely physical stability of solid dispersions