… different patterns of drug and polymer release from amorphous solid dispersions as a
function of drug loading that appear to depend on polymer hydrophobicity. Drug release from …

… Amorphous solid dispersion formulations (ASD) are … soluble drugs. One of the limitations
of ASDs, in particular for high glass transition temperature (T g ) compounds, is the drug loading …

… the performance of a dispersion, by combining a polymer that rapidly releases the drug, but
is … In the current study, high drug loading ASDs formulated with PVP and HPMC or HPMCAS …

… High drug load amorphous solid dispersions (ASDs) have been a challenge to formulate
partially because drug release is inhibited at high drug loads. The maximum drug load prior to …

… the ASD dissolution performance as a function of drug loading, we chose to vary the TPGS
… amorphous solid dispersions of felodipine, PVPVA, and TPGS at different drug loadings, as …

… is the most suited for a given drug-polymer combination at various process conditions.
For example, high drug loading amorphous solid dispersion (HDASD, drug loading > 50% w/w), …

… physically stable high-loading dose amorphous dispersions, we will first briefly review
some factors which play a general role in polymer stabilization of amorphous API molecules, …

… soluble drug is amorphous solid dispersion (ASD), where the drug is … Dissolving an amorphous
drug or an ASD formulation can … rate of drugs from amorphous solid dispersions are not …

… The controlling factor in their dissolution was found to change from the physicochemical
properties of the polymer to the solubility of the amorphous drug layer when the drug load in the …

… to amorphous drug. Unlike chemical crosslinking, in our approach, amorphous solid dispersions
(ASDs) … Hence, ASDs with 95% drug loading whereas in chemical crosslinking the drug …