Coronavirus disease (COVID-19): Current status and prospects for drug and vaccine development

K Ita - Archives of medical research, 2021 - Elsevier
… are numerous potential approaches to pharmacologically fight COVID-19: small-molecule
drugs, … This review focuses on the drugs and vaccines being developed against the COVID-19. …

Antihypertensive drugs and risk of COVID-19?

CJ Tignanelli, NE Ingraham, MA Sparks… - The Lancet …, 2020 - thelancet.com
… Fang and colleagues postulate that patients with SARS-CoV-2 treated with ARBs and
ACEIs are at a higher risk for severe COVID-19 infection because of a potential upregulation of …

COVID-19: Pathogenesis, cytokine storm and therapeutic potential of interferons

SH Nile, A Nile, J Qiu, L Li, X Jia, G Kai - Cytokine & growth factor reviews, 2020 - Elsevier
… Clinical investigations in patients with COVID-19 has shown a strong … -19 associated mortality.
To date, no specific therapeutic drugs or vaccines are available to treat COVID-19 patients…

[HTML][HTML] Drug repositioning: new approaches and future prospects for life-debilitating diseases and the COVID-19 pandemic outbreak

ZY Low, IA Farouk, SK Lal - Viruses, 2020 - mdpi.com
… drug of choice as it can be produced on a larger scale for global distribution compared to
other potential drugs against COVID-19 such as Remdesivir [87]. Moreover, it has a proven …

[HTML][HTML] Anti-COVID-19 drug candidates: A review on potential biological activities of natural products in the management of new coronavirus infection

A Prasansuklab, A Theerasri, P Rangsinth… - Journal of Traditional …, 2021 - Elsevier
… , we provide a total of 150 natural compounds as potential candidates for development of
new anti-COVID-19 drugs with higher efficacy and lower toxicity than the existing therapeutic …

[HTML][HTML] Potential use of hydroxychloroquine, ivermectin and azithromycin drugs in fighting COVID-19: trends, scope and relevance

R Choudhary, AK Sharma - New microbes and new infections, 2020 - Elsevier
… the spread of COVID-19. Towards that initiative, potential drugs like hydroxychloroquine, …
group of researchers worldwide for their potential against novel coronavirus. The present report …

Current status and strategic possibilities on potential use of combinational drug therapy against COVID-19 caused by SARS-CoV-2

AJ Siddiqui, S Jahan, SA Ashraf… - Journal of …, 2021 - Taylor & Francis
… for the treatment of COVID-19. However, some potential antimalarial drugs like
hydroxychloroquine and azithromycin, antifilarial drug ivermectin and antiviral drugs have been …

[HTML][HTML] Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
… host factors are potential targets for … of COVID-19 have been classified into “target virus”
and “target host” categories. Repurposing drugs, emerging approaches, and promising potential

Potential biases in studies of acid-suppressing drugs and COVID-19 infection

M Etminan, M Nazemipour, MA Mansournia - Gastroenterology, 2021 - gastrojournal.org
… of PPIs or H2RAs for COVID-19 prevention. Here we discuss potential biases that might have
led to … rigor of observational studies addressing COVID-19 in the area of gastroenterology. …

An effective drug against COVID-19: reality or dream?

A Yaghoubi, S Amel Jamehdar, A Movaqar… - Expert Review of …, 2021 - Taylor & Francis
drugs for the treatment of this disease. Most of these drugs with the antiviral potential effect
toward COVID-19 are … Some drugs that show the promising therapeutic potential in the initial …