Type I Interferons are the hallmark cytokines deployed during infection to combat invading
viruses. However, inflammatory cytokines such as Interleukin (IL)-1β and IL-18 also play …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Viral diseases are the most common problems threatening human health, livestock, and
poultry industries worldwide. Viral infection is a complex and competitive dynamic biological …

Inflammasomes are protein complexes that form in response to pathogen-derived or host-
derived stress signals. Their activation leads to the production of inflammatory cytokines and …

Through their capacity to sense danger signals and to generate active interleukin-1β (IL-1β),
inflammasomes occupy a central role in the inflammatory response. In contrast to IL-1β, little …

Highlights•Functional degradation is an essential step in NLRP1b inflammasome
activation.•Site-specific cleavage of caspase-11/4/5 generates an enzymatically active …

Over recent years, inflammasomes have emerged as key regulators of immune and
inflammatory responses. They induce programmed cell death and direct the release of …

Inflammasomes are cytosolic multiprotein complexes that sense microbial motifs or cellular
stress and stimulate caspase-1-dependent cytokine secretion and cell death. Recently, it …

Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …

Pro-inflammatory cytokines are important mediators in immune responses against invading
pathogens, including viruses. Precursors of the pro-inflammatory cytokines interleukin (IL) …