Induction, production, and release of proinflammatory cytokines are essential steps to
establish an effective host defense. Cytokines of the interleukin-1 (IL-1) family induce …

Introduction The innate immune system orchestrates inflammatory responses to
microorganisms or danger-associated molecular patterns generated, for example, by the …

The importance of innate immunity lies not only in directly confronting pathogenic and non-
pathogenic insults but also in instructing the development of an efficient adaptive immune …

Inflammasomes are immune cytosolic oligomers involved in the initiation and progression of
multiple pathologies and diseases. The tight regulation of these immune sensors is …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

The cells of the innate immune system mobilize a coordinated immune response towards
invading microbes and after disturbances in tissue homeostasis. These immune responses …

Inflammasomes are cytosolic polyprotein complexes formed in response to various external
and internal stimuli, including viral and bacterial antigens. The main product of the …

Interleukin-1β (IL-1β) and IL-18 contribute to host defense against infection by augmenting
antimicrobial properties of phagocytes and initiating Th1 and Th17 adaptive immune …

Introduction: The inflammasomes have emerged as key mediators of inflammation and
immunity, yet clinical application of this knowledge has been limited by a lack of specific and …

The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and
IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is …