Inflammasomes are emerging as key regulators of the host response against microbial
pathogens. These cytosolic multiprotein complexes recruit and activate the cysteine …

Inflammasomes are protein complexes of the innate immune system that initiate
inflammation in response to either exogenous pathogens or endogenous danger signals …

Human beings are constantly exposed to pathogens. The innate immune system is the first
line of defense against microbes. It has evolved to recognize conserved microbial motifs …

Inflammasomes are a group of cytosolic multiprotein complexes that are assembled in
response to pathogen-and damage-associated molecular patterns and cellular stress …

The understanding of the innate immunity, the first line of the host defence, was significantly
modified following the sequential discovery of innate immune receptors such as the Toll-like …

Inflammasomes are signalling platforms that sense a diverse range of microbial products
and also a number of stress and damage associated endogenous signals. Inflammasome …

Inflammasomes are cytosolic multi-molecular complexes that sense intracellular microbial
danger signals and metabolic perturbations. Inflammasome activation leads to the activation …

Inflammasome complexes and their integral receptor proteins have essential roles in
regulating the innate immune response and inflammation at the post-translational level. Yet …

Inflammation is a body's protective mechanism to eliminate invading pathogens and cellular
damaging signals. The inflammatory response consists of two main consecutive steps—a …

Inflammasomes are multiprotein complexes that serve as activating platforms for the enzyme
caspase-1 in response to various danger signals. Active caspase-1 can cleave the …