Inflammasomes are intracellular multiprotein signaling complexes, mainly present in
myeloid cells. They commonly assemble around a cytoplasmic receptor of the nucleotide …

Caspase 1 activation by inflammasome complexes in response to pathogen-associated
molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) induces …

In addition to its roles in controlling infection and tissue repair, inflammation plays a critical
role in diverse and distinct chronic diseases, such as cancer, metabolic syndrome, and …

Inflammasomes are macromolecular complexes formed in response to pathogen‐
associated molecular patterns (PAMPs) and danger‐associated molecular patterns …

A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

Inflammasomes are intracellular protein complexes that sense microbial components and
damage of infected cells. Following activation by molecules released by pathogens or …

Through its ability to control the proteolytic maturation and secretion of interleukin-1 family
cytokines, the inflammasome occupies a central role in the activation of inflammation and …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Inflammation is the coordinated immune response to harmful stimuli that appear during
infections or after tissue damage. Cells of the innate immune system are the central players …