The inflammasome is a macromolecular protein complex that mediates proteolytic cleavage
of pro-IL-1β and-IL-18 and induces cell death in the form of pyroptosis. Certain nucleotide …

Highlights•Advances in ALR mediated inflammasome activation in response to viral
DNA.•Viral virulence factors that impair inflammasome activation.•Host regulation of …

Cardiovascular disease (CVD) is the number one cause of death worldwide. The
pathogenesis of various disease entities that comprise the area of CVD is complex and …

Over the past decade, numerous advances have been made in the role and regulation of
inflammasomes during pathogenic and sterile insults. An inflammasome complex comprises …

Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-
1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or …

In response to injurious or infectious agents caspase-1 activating multiprotein complexes,
termed inflammasomes, assemble in the cytoplasm of cells. Activated caspase-1 cleaves the …

Inflammasomes are multimeric protein complexes that regulate inflammatory responses and
pyroptotic cell death to exert host defense against microbes. Intracellular pattern-recognition …

The inflammasomes are critical regulators of innate immunity, inflammation and cell death
and have emerged as important regulators of cancer development and control …

The NLR (nucleotide-binding domain leucine-rich repeat containing) family of intracellular
sensors is a crucial component of the innate immune system. A number of NLR family …

Germline-encoded pattern recognition receptors (PRRs) sense microbial or endogenous
products released from damaged or dying cells and trigger innate immunity. In most cases …