A dose-ranging study in older adults to compare the safety and immunogenicity profiles of MF59®-adjuvanted and non-adjuvanted seasonal influenza vaccines …

G Della Cioppa, U Nicolay, K Lindert… - Human vaccines & …, 2014 - Taylor & Francis
Strategies to optimize responses to seasonal influenza vaccination in older adults include
the use of adjuvants, higher antigen doses, and intradermal delivery. In this study adults …

Comparison of the immunogenicity and safety of the conventional subunit, MF59-adjuvanted, and intradermal influenza vaccines in the elderly

YB Seo, WS Choi, J Lee, JY Song… - Clinical and vaccine …, 2014 - Am Soc Microbiol
The influenza vaccination is known as the most effective method for preventing influenza
infection and its complications in the elderly. Conventional subunit (Agrippal S1; Novartis) …

Superior immunogenicity of seasonal influenza vaccines containing full dose of MF59® adjuvant: Results from a dose-finding clinical trial in older adults

G Della Cioppa, U Nicolay, K Lindert… - Human vaccines & …, 2012 - Taylor & Francis
Background: MF59-adjuvanted influenza vaccines have superior immunogenicity in older
adults compared with non-adjuvanted vaccines. We assessed whether changing formulation …

[HTML][HTML] Safety and immunogenicity of an MF59™-adjuvanted subunit influenza vaccine in elderly Chinese subjects

R Li, H Fang, Y Li, Y Liu, M Pellegrini, A Podda - Immunity & Ageing, 2008 - Springer
Background The safety and immunogenicity of an MF59™-adjuvanted subunit influenza
vaccine (Sub/MF59™; FLUAD®, Novartis Vaccines) was evaluated among elderly Chinese …

MF59-adjuvanted versus non-adjuvanted influenza vaccines: integrated analysis from a large safety database

M Pellegrini, U Nicolay, K Lindert, N Groth… - Vaccine, 2009 - Elsevier
BACKGROUND: Adding adjuvants such as MF59® to influenza vaccines can enhance the
immune response. This analysis evaluated the safety profile of MF59-adjuvanted [(+) MF59] …

[HTML][HTML] Immunogenicity and safety of Fluzone® intradermal and high-dose influenza vaccines in older adults≥ 65 years of age: A randomized, controlled, phase II …

P Tsang, GJ Gorse, CB Strout, M Sperling… - Vaccine, 2014 - Elsevier
We conducted a randomized, controlled, multicenter, phase II study to evaluate the
immunogenicity and safety of an investigational intradermal (ID) trivalent influenza vaccine …

Comparison of the safety and immunogenicity of an MF59®-adjuvanted with a non-adjuvanted seasonal influenza vaccine in elderly subjects

SE Frey, MR Aplasca-De Los Reyes, H Reynales… - Vaccine, 2014 - Elsevier
Aim Adjuvanted influenza vaccines can overcome the poor antibody response of
conventional non-adjuvanted vaccines in the elderly. We evaluated the immunogenicity …

Immunogenicity of intramuscular MF59-adjuvanted and intradermal administered influenza enhanced vaccines in subjects aged over 60: a literature review

B Camilloni, M Basileo, S Valente… - Human vaccines & …, 2015 - Taylor & Francis
Because of the age-related immune system decline, 2 potentiated influenza vaccines were
specifically licensed for the elderly: Fluad®, an MF59-adjuvanted vaccine administered …

Comparison of the safety, tolerability, and immunogenicity of a MF59-adjuvanted influenza vaccine and a non-adjuvanted influenza vaccine in non-elderly adults

S Frey, G Poland, S Percell, A Podda - Vaccine, 2003 - Elsevier
The adjuvanted influenza vaccine FLUAD™ is composed of subunit influenza antigens
combined with the MF59-adjuvant emulsion. The vaccine was developed primarily for use in …

MF59™-adjuvanted subunit influenza vaccine: an improved interpandemic influenza vaccine for vulnerable populations

J Puig Barberà, D González Vidal - Expert review of vaccines, 2007 - Taylor & Francis
Influenza is a highly contagious respiratory disease associated with substantial morbidity
and mortality in vulnerable populations, especially the elderly. Influenza viruses are unique …