Leveraging congested catalyst scaffolds has emerged as a key strategy for altering innate
substrate site-selectivity profiles in C–H functionalization reactions. Similar to enzyme active …

Achieving selective C–H functionalization is a significant challenge that requires
discrimination between many similar C–H bonds. Yet, reaction systems employing Rh2 …

Interactions between catalysts and substrates can be highly complex and dynamic, often
complicating the development of models to either predict or understand such processes. A …

CpXRh (III)-catalyzed C–H functionalization reactions are a proven method for the efficient
assembly of small molecules. However, rationalization of the effects of cyclopentadienyl …

Computational studies on the dirhodium (tetracarboxylate)-catalyzed C–H functionalization
with donor/acceptor carbenes reveal that the enantioselectivity and site-selectivity of this …

Aromatic C–H functionalization reactions are an important part of the synthetic chemistry
toolbox. Accurate prediction of site selectivity can be crucial for prioritizing target compounds …

The C–H functionalization of silyl ethers via carbene-induced C–H insertion represents an
efficient synthetic disconnection strategy. In this work, site-and stereoselective C (sp3)–H …

Catalyst-controlled C–H functionalization using donor/acceptor carbenes has been shown to
be an efficient process capable of high levels of site control and stereocontrol. This study …

Intermolecular C (sp3)–H insertions of β-carbonyl ester dirhodium-carbenes are extremely
rare. Toward developing efficient reactions of these carbenes, a model for their insertion into …

A special type of C–H functionalization can be achieved through C–H insertion combined
with Cope rearrangement (CHCR) in the presence of dirhodium catalysts. This type of …