The present review is devoted to summarizing the recent advances (2015–2017) in the field
of metal-catalysed group-directed C–H functionalisation. In order to clearly showcase the …

D 2-symmetric dirhodium (II) carboxylate catalysts that bear axially chiral
binaphthothiophene δ-amino acid derivatives have been developed. Conformational control …

With over 10,000 new reaction protocols arising every year, only a handful of these
procedures transition from academia to application. A major reason for this gap stems from …

Catalyst-controlled C–H functionalization by means of the C–H insertion chemistry of
rhodium carbenes has become a powerful synthetic method. The key requirements for the …

The ability to devise and design multifunctional active sites at the nanoscale, by drawing on
the intricate ability of enzymes to evolve single-sites with distinctive catalytic function, has …

C–H functionalisation promises a paradigm shift in synthetic planning. However, the
additional steps often required to install and remove directing groups currently detract from …

In an effort to augment or displace petroleum as a source of liquid fuels and chemicals,
researchers are seeking lower cost technologies that convert natural gas (largely methane) …

The atomistic change of C (sp3)–H to C (sp3)–O can have a profound impact on the physical
and biological properties of small molecules. Traditionally, chemical synthesis has relied on …

INTRODUCTION The development of new synthetic methods in organic chemistry is
traditionally accomplished through empirical optimization. Catalyst design, wherein …

A new class of reagents is described for C–H functionalization by means of C–H insertion
using donor/acceptor-substituted rhodium (II) carbene intermediates. The 2, 2, 2 …