Highlights•The innate immune system utilizes a set of multiprotein complexes called
inflammasomes that can be triggered during infection.•Inflammasome activation supports …

The innate immune system plays a critical role in defense against microbial infection and
employs germline-encoded pattern recognition receptors to detect broadly conserved …

Highlights•Functional degradation is an essential step in NLRP1b inflammasome
activation.•Site-specific cleavage of caspase-11/4/5 generates an enzymatically active …

The immune system of multicellular organisms protects them from harmful microbes. To
establish an infection in the face of host immune responses, pathogens must evolve specific …

One of the most fascinating riddles in immune biology is how vertebrates can sense the
presence of a broad variety of highly diverse pathological agents. In response to this …

The innate immune system serves to generate immediate host defenses against pathogens.
Advance in the mechanism of innate immunity has provided new insights into host-pathogen …

Inflammasomes are emerging as key regulators of the host response against microbial
pathogens. These cytosolic multiprotein complexes recruit and activate the cysteine …

Inflammasome signaling impinges on the activation of inflammatory caspases (ie, caspase-1
and caspase-4/5/11) and endows host cells with a sentinel system to sense microbial …

The innate immune system is a dynamic and complex network for recognizing and
responding to cellular insult or tissue damage after infection or injury. The primary effector …

Activation of the inflammatory cysteine protease caspase-1 in inflammasome complexes
plays a critical role in the host response to microbial infections. Inflammasome activation …