Background: Older people (≥ 60 years old) are particularly vulnerable to influenza virus
infection, and vaccine is effective in reducing the disease burden in this population …

Introduction Older adults are prioritized for influenza vaccination but also have lowered
antibody responses to the vaccine. Higher-doses of influenza antigen may increase immune …

Background A number of enhanced influenza vaccines have been developed for use in
older adults, including high-dose, MF59-adjuvanted, and intradermal vaccines. Methods We …

Background Enhanced influenza vaccines may improve protection for older adults, but
comparative immunogenicity data are limited. Our objective was to examine immune …

Introduction The influenza vaccine is less immunogenic in older than younger adults, and
the duration of protection is unclear. Determining if protection persists beyond a typical …

Background Influenza-associated morbidity and mortality has not decreased in the last
decade, despite increased receipt of vaccine. To improve the immunogenicity of influenza …

Foremost amongst the diseases preventable by vaccination is influenza. Worldwide,
influenza virus infection is associated with serious adverse events leading to hospitalization …

Background Influenza vaccination of elderly individuals is recommended worldwide. Our
aim was to review the evidence of efficacy and effectiveness of influenza vaccines in …

Background Several aggregate data meta-analyses have provided estimates of the
effectiveness of influenza vaccination in community-dwelling elderly people. However, these …

The exact magnitude of the benefit of influenza vaccine among elderly individuals is subject
of considerable debated. Existing vaccine effectiveness estimates come mostly from …