Lipid-based Nanocarriers for mRNA Delivery: Vital Considerations and Applications

T Sharma, MA Babu, A Jain… - … & Nanotechnology-Asia, 2024 - ingentaconnect.com
The use of mRNA in therapeutics has lately emerged as a powerful strategy for alleviating
the various viral infections and diseased conditions, along with prophylaxis. However, a key …

Advancing Cancer Immunotherapy: The Potential of mRNA Vaccines As a Promising Therapeutic Approach

F Goyal, A Chattopadhyay, U Navik, A Jain… - Advanced …, 2024 - Wiley Online Library
Abstract mRNA vaccines have long been recognized for their ability to induce robust
immune responses. The discovery that mRNA vaccines may also contribute to antitumor …

Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety

I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …

Brief Insights into mRNA Vaccines: Their Successful Production and Nanoformulation for Effective Response against COVID-19 and Their Potential Success for …

A Parveen, AA Elkordy - Pathogens, 2024 - mdpi.com
A mRNA vaccine is a type of vaccine that induces an immune response. Antigen-encoding
mRNA is delivered via vaccine carriers into the immune cells, which are produced because …

Nanomaterial delivery systems for mRNA vaccines

MD Buschmann, MJ Carrasco, S Alishetty, M Paige… - Vaccines, 2021 - mdpi.com
The recent success of mRNA vaccines in SARS-CoV-2 clinical trials is in part due to the
development of lipid nanoparticle delivery systems that not only efficiently express the …

Lipid Nanoparticle-Mediated Delivery of Therapeutic and Prophylactic mRNA: Immune Activation by Ionizable Cationic Lipids

M Ongun, AG Lokras, C Foged, A Thakur - Messenger RNA Therapeutics, 2022 - Springer
Messenger RNA (mRNA) can be harnessed as vaccines and therapeutic drugs via transient
in situ expression of protein antigens and therapeutic proteins, respectively. Currently …

The potential of mRNA vaccines in cancer nanomedicine and immunotherapy

S Pan, R Fan, B Han, A Tong, G Guo - Trends in Immunology, 2024 - cell.com
Owing to their outstanding performance against COVID-19, mRNA vaccines have brought
great hope for combating various incurable diseases, including cancer. Differences in the …

mRNA vaccine delivery using lipid nanoparticles

AM Reichmuth, MA Oberli, A Jaklenec… - Therapeutic …, 2016 - Taylor & Francis
mRNA vaccines elicit a potent immune response including antibodies and cytotoxic T cells.
mRNA vaccines are currently evaluated in clinical trials for cancer immunotherapy …

RNA cancer vaccines: developing mRNA nanovaccine with self-adjuvant property for cancer immunotherapy

H Zhang, X Xia - Human Vaccines & Immunotherapeutics, 2021 - Taylor & Francis
Messenger RNA (mRNA)-based cancer vaccine has become a popular approach for
developing personalized and effective antitumor immunotherapy. To achieve robust …

Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects

SH Kiaie, N Majidi Zolbanin, A Ahmadi… - Journal of …, 2022 - Springer
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid
nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of …