Improving dissolution performance and drug loading of amorphous dispersions through a hierarchical particle approach

TN Hiew, S Saboo, DY Zemlyanov, A Punia… - Journal of …, 2023 - Elsevier
Co-precipitation is an emerging manufacturing strategy for amorphous solid dispersions
(ASDs). Herein, the interplay between processing conditions, surface composition, and …

Coprecipitated amorphous dispersions as drug substance: opportunities and challenges

NA Strotman, L Schenck - Organic Process Research & …, 2021 - ACS Publications
The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at …

L Schenck, AKP Mann, Z Liu, M Milewski… - International journal of …, 2019 - Elsevier
Amorphous solid dispersions are a promising option for managing compounds with poor
aqueous solubility. However, for compounds with high melting points, thermal stability …

[HTML][HTML] Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole

D Frank, L Schenck, A Koynov, Y Su, Y Li… - Pharmaceutics, 2021 - mdpi.com
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …

Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance

M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …

[HTML][HTML] Hierarchical particle approach for co-precipitated amorphous solid dispersions for use in preclinical in vivo studies

L Schenck, C Boyce, D Frank, S Koranne… - Pharmaceutics, 2021 - mdpi.com
Amorphous solid dispersions (ASD) have become a well-established strategy to improve
exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs …

Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations

B Démuth, ZK Nagy, A Balogh, T Vigh, G Marosi… - International journal of …, 2015 - Elsevier
Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …

Design of a re-dispersible high drug load amorphous formulation

HS Oberoi, F Arce, HS Purohit, M Yu, CA Fowler… - Journal of …, 2023 - Elsevier
Amorphous solid dispersions (ASD) are a commonly used enabling formulation technology
to drive oral absorption of poorly soluble drugs. To ensure adequate solid-state stability and …

High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units

DS Frank, H Nie, A Chandra, A Coelho, C Dalton… - Journal of …, 2023 - Elsevier
Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of
poorly water-soluble compounds. However, the material attributes of ASDs can present …

Sustained-release amorphous solid dispersions

J Maincent, RO Williams III - Drug Delivery and Translational Research, 2018 - Springer
The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …