Improving dissolution performance and drug loading of amorphous dispersions through a hierarchical particle approach
Co-precipitation is an emerging manufacturing strategy for amorphous solid dispersions
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
(ASDs). Herein, the interplay between processing conditions, surface composition, and …
Coprecipitated amorphous dispersions as drug substance: opportunities and challenges
NA Strotman, L Schenck - Organic Process Research & …, 2021 - ACS Publications
The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …
Building a better particle: Leveraging physicochemical understanding of amorphous solid dispersions and a hierarchical particle approach for improved delivery at …
Amorphous solid dispersions are a promising option for managing compounds with poor
aqueous solubility. However, for compounds with high melting points, thermal stability …
aqueous solubility. However, for compounds with high melting points, thermal stability …
[HTML][HTML] Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …
notable for its ability to enable the production of ASDs containing pharmaceuticals with …
Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance
M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
[HTML][HTML] Hierarchical particle approach for co-precipitated amorphous solid dispersions for use in preclinical in vivo studies
Amorphous solid dispersions (ASD) have become a well-established strategy to improve
exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs …
exposure for compounds with insufficient aqueous solubility. Of methods to generate ASDs …
Downstream processing of polymer-based amorphous solid dispersions to generate tablet formulations
Application of amorphous solid dispersions (ASDs) is considered one of the most promising
approaches to increase the dissolution rate and extent of bioavailability of poorly water …
approaches to increase the dissolution rate and extent of bioavailability of poorly water …
Design of a re-dispersible high drug load amorphous formulation
Amorphous solid dispersions (ASD) are a commonly used enabling formulation technology
to drive oral absorption of poorly soluble drugs. To ensure adequate solid-state stability and …
to drive oral absorption of poorly soluble drugs. To ensure adequate solid-state stability and …
High bulk-density amorphous dispersions to enable direct compression of reduced tablet size amorphous dosage units
Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of
poorly water-soluble compounds. However, the material attributes of ASDs can present …
poorly water-soluble compounds. However, the material attributes of ASDs can present …
Sustained-release amorphous solid dispersions
J Maincent, RO Williams III - Drug Delivery and Translational Research, 2018 - Springer
The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …
相关搜索
- amorphous dispersions dissolution performance
- amorphous dispersions drug loading
- drug loading dissolution performance
- processing and performance amorphous formulations
- drug loadings physicochemical understanding
- amorphous dispersions tablet size
- amorphous dispersions dosage units
- amorphous dispersions direct compression
- nonionic surfactants drug load
- amorphous dispersions bulk density
- processing and performance drug load
- amorphous formulations drug load