We performed a quantitative review of 31 vaccine antibody response studies conducted from
1986 to 2002 and compared antibody responses to influenza vaccine in groups of elderly …

Although a number of studies have investigated and quantified immune correlates of
protection against influenza in adults and children, data on immune protection in the elderly …

The objective of this study was to determine the immune response to influenza vaccination
in elderly people, using a randomized, double-blind, placebo-controlled trial. Venous blood …

Elderly individuals not only demonstrate a greater risk of morbidity and mortality from
influenza than the young, but also have greater difficulty mounting a protective response to …

Conflicting results have been reported concerning the association between high age and
response to influenza vaccines. Some authors have found a reduced response in aged …

Advisory committees have cautioned that influenza vaccine-induced antibody declines more
rapidly in the elderly, falling below seroprotective levels within 4 months. Weconducted a …

The elderly have been considered as the priority group for influenza vaccination, but their
influenza vaccine-induced antibody was believed to decline more rapidly. Long-term …

The most profound consequences of immune senescence with respect to public health are
the increased susceptibility to influenza and loss of efficacy of the current split-virus …

Objective: Each year, influenza and its complications account for 10,000-40,000 excess
deaths in the United States. Over 80% of these deaths occur among the elderly. The …

During seasonal influenza epidemics, disease burden is shouldered predominantly by the
very young and the elderly. Elderly individuals are particularly affected, in part because …