Vaccination is the best method for the prevention and control of influenza. Vaccination can
reduce illness and lessen severity of infection. This review focuses on how currently …

Background Current influenza virus vaccines are effective when well matched to the
circulating strains. Unfortunately, antigenic drift and the high diversity of potential emerging …

The main barrier to reduction of morbidity caused by influenza is the absence of a vaccine
that elicits broad protection against different virus strains. Studies in preclinical models of …

Influenza viruses pose a permanent threat to human populations due to their ability to
constantly adapt to impact immunologically susceptible individuals in the forms of epidemic …

Highlights•Early viral infections shape B cell response recalled against future viral
strains.•Competition between memory and naïve B cells occurs in secondary viral …

Influenza is a highly infectious airborne disease with an important epidemiological and
societal burden; annual epidemics and pandemics have occurred since ancient times …

Influenza viruses continue to be a major public health concern, despite the availability of
vaccines. Currently licensed influenza vaccines aim at the induction of antibodies that target …

Introduction: I propose that influenza vaccine failure be defined as receipt of a properly
stored and administered vaccine with the subsequent development of documented …

Influenza virus frequently mutates due to its error-prone polymerase. This feature contributes
to influenza virus's ability to evade pre-existing immunity, leading to annual epidemics and …

The possible emergence of a new influenza pandemic is considered a major threat for
human health worldwide. Pandemics start by the introduction or reintroduction and spread in …