The innate immune system serves to generate immediate host defenses against pathogens.
Advance in the mechanism of innate immunity has provided new insights into host-pathogen …

One of the most fascinating riddles in immune biology is how vertebrates can sense the
presence of a broad variety of highly diverse pathological agents. In response to this …

The innate immune system is a dynamic and complex network for recognizing and
responding to cellular insult or tissue damage after infection or injury. The primary effector …

Activation of the inflammasome occurs in response to infection with a wide array of
pathogenic microbes. The inflammasome serves as a platform to activate caspase-1, which …

Pathogens frequently exist in an immunological balancing act with their host. Pathogens
must not only replicate within a host but also transmit effectively between hosts to perpetuate …

Highlights•The innate immune system utilizes a set of multiprotein complexes called
inflammasomes that can be triggered during infection.•Inflammasome activation supports …

The complementary actions of the innate and adaptive immune systems often provide
effective host defense against microbial pathogens and harmful environmental agents …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

The innate immune system plays a critical role in defense against microbial infection and
employs germline-encoded pattern recognition receptors to detect broadly conserved …

The inflammasome is an important innate immune pathway that regulates at least two host
responses protective against infections:(1) secretion of the proinflammatory cytokines IL‐1β …