The inflammasome is a large multiprotein complex whose assembly leads to the activation
of caspase-1, which promotes the maturation of proinflammatory cytokines interleukin-1β (IL …

Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response
to a number of exogenous and endogenous danger signals, leading to the production of pro …

In response to injurious or infectious agents caspase-1 activating multiprotein complexes,
termed inflammasomes, assemble in the cytoplasm of cells. Activated caspase-1 cleaves the …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

The NOD-like receptors have important roles in innate immunity as intracellular sensors of
microbial components and cell injury. It has been proposed that these cytosolic proteins …

Inflammasome biology is one of the most exciting and rapidly growing areas in immunology.
Over the past 10 years, inflammasomes have been recognized for their roles in the host …

Inflammasomes are cytosolic multiprotein platforms assembled in response to invading
pathogens and other danger signals. Typically inflammasome complexes contain a sensor …

The inflammasome is a multiprotein complex that mediates the activation of caspase-1,
which promotes secretion of the proinflammatory cytokines interleukin 1β (IL-1β) and IL-18 …

The adapter molecules ASC, Ipaf and Cryopyrin/Nalp3 have each been proposed to
regulate caspase-1 within a multi-protein complex called the “inflammasome”. Activation of …

The NALP3-inflammasome is a protein complex that stimulates caspase-1 activation to
promote the processing and secretion of proinflammatory cytokines. Recent work indicates …