Densifying co-precipitated amorphous dispersions to achieve improved bulk powder properties
Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …
pharmaceutical industry given its application to pharmaceuticals with varying …
Delivery of poorly soluble compounds by amorphous solid dispersions
T WY Lee, NA Boersen, HW Hui… - Current …, 2014 - ingentaconnect.com
Solid state manipulation by amorphous solid dispersion has been the subject of intensive
research for decades due to their excellent potential for dissolution and bioavailability …
research for decades due to their excellent potential for dissolution and bioavailability …
Producing amorphous solid dispersions via co-precipitation and spray drying: impact to physicochemical and biopharmaceutical properties
Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous
solubility and benefit from generation of amorphous dispersions of the API and polymer to …
solubility and benefit from generation of amorphous dispersions of the API and polymer to …
Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance
M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …
Amorphous solid dispersions: Rational selection of a manufacturing process
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
most exciting areas in the pharmaceutical field. This approach presents huge potential and …
Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design
JA Lugtu-Pe, A Ghaffari, K Chen, A Kane… - European Journal of …, 2018 - Elsevier
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …
Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion
J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …
in vitro and in vivo performances of poorly water-soluble drugs, such as …
Amorphous solid dispersions: a robust platform to address bioavailability challenges
A Newman, K Nagapudi, R Wenslow - Therapeutic delivery, 2015 - Future Science
Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …
soluble pharmaceutical compounds in development. These systems consist of an …
Characterization of amorphous solid dispersions
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …
Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations
SK Saha, A Joshi, R Singh, K Dubey - Pharmaceutical …, 2023 - Taylor & Francis
Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …