Densifying co-precipitated amorphous dispersions to achieve improved bulk powder properties

DS Frank, A Punia, M Fahy, C Dalton, J Rowe… - Pharmaceutical …, 2022 - Springer
Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …

Delivery of poorly soluble compounds by amorphous solid dispersions

T WY Lee, NA Boersen, HW Hui… - Current …, 2014 - ingentaconnect.com
Solid state manipulation by amorphous solid dispersion has been the subject of intensive
research for decades due to their excellent potential for dissolution and bioavailability …

Producing amorphous solid dispersions via co-precipitation and spray drying: impact to physicochemical and biopharmaceutical properties

AKP Mann, L Schenck, A Koynov… - Journal of …, 2018 - Elsevier
Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous
solubility and benefit from generation of amorphous dispersions of the API and polymer to …

Design of Redispersible High-Drug-Load Amorphous Formulations: Impact of Ionic vs Nonionic Surfactants on Processing and Performance

M Yu, HS Oberoi, HS Purohit, CA Fowler… - Molecular …, 2023 - ACS Publications
Amorphous solid dispersions (ASDs) are an enabling formulation approach used to
enhance bioavailability of poorly water-soluble molecules in oral drug products. Drug-rich …

Amorphous solid dispersions: Rational selection of a manufacturing process

T Vasconcelos, S Marques, J das Neves… - Advanced drug delivery …, 2016 - Elsevier
Amorphous products and particularly amorphous solid dispersions are currently one of the
most exciting areas in the pharmaceutical field. This approach presents huge potential and …

Development of controlled release amorphous solid dispersions (CRASD) using polyvinyl acetate-based release retarding materials: Effect of dosage form design

JA Lugtu-Pe, A Ghaffari, K Chen, A Kane… - European Journal of …, 2018 - Elsevier
The amorphous solid dispersion (ASD) technique has been employed to formulate poorly-
soluble drugs, however, development of solid dosage forms with ASD is challenging due to …

Amorphous solid dispersions: Stability mechanism, design strategy and key production technique of hot melt extrusion

J Han, M Tang, Y Yang, W Sun, Z Yue, Y Zhang… - International Journal of …, 2023 - Elsevier
Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Amorphous solid dispersions: a robust platform to address bioavailability challenges

A Newman, K Nagapudi, R Wenslow - Therapeutic delivery, 2015 - Future Science
Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …

Characterization of amorphous solid dispersions

X Liu, X Feng, RO Williams, F Zhang - Journal of Pharmaceutical …, 2018 - Springer
The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …

Review of industrially recognized polymers and manufacturing processes for amorphous solid dispersion based formulations

SK Saha, A Joshi, R Singh, K Dubey - Pharmaceutical …, 2023 - Taylor & Francis
Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …