Purpose The purpose of this work is to evaluate the interrelationship of microstructure,
properties, and dissolution performance for amorphous solid dispersions (ASDs) prepared …

Background: The current challenge in drug development lies in addressing the
physicochemical issues that lead to low drug effectiveness. Solubility, a crucial …

A novel solvent controlled precipitation (SCP) process based on microfluidization was
assessed to produce solid dispersions of carbamazepine, a poorly water-soluble drug with …

Amorphous solid dispersions (ASDs) are commonly used to orally deliver small-molecule
drugs that are poorly water-soluble. ASDs consist of drug molecules in the amorphous form …

Over the past few decades, co-amorphous solids have been used as a promising approach
for delivering poorly water-soluble drugs. Co-amorphous solids, comprising …

In this paper, we establish a mechanistic model for the prediction of amorphous solid
dispersion (ASD) stability. The novel approach incorporates fundamental physical …

Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …

The formulation of oral amorphous solid dispersions (ASD) includes the use of excipients to
improve physical stability and enhance bioavailability. Combinations of excipients (polymers …

Enzalutamide is a fast crystallizing, hydrophobic compound that has solubility limited
absorption in vivo. Given the low aqueous solubility of this compound, it was of interest to …

There is a growing interest in the pharmaceutical industry to develop amorphous solid
dispersions (ASDs) of poorly aqueous soluble drugs due to their higher supersaturation …