Evolving therapeutic landscape through combinatorial chemistry and high throughput
screening have resulted in an increased number of poorly soluble drugs. Drug delivery …

Amorphous solid dispersion (ASD) is one of the most effective approaches for delivering
poorly soluble drugs. In ASDs, polymeric materials serve as the carriers in which the drugs …

In recent years amorphous solid dispersions (ASD) has gained a tremendous response for
improving the solubility of poorly water-soluble drug substances. Despite the stability …

Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

Amorphous solid dispersion (ASD) can accelerate a project by improving dissolution rate
and solubility, offering dose escalation flexibility and excipient acceptance for toxicology …

The poor aqueous solubility of many active pharmaceutical ingredients (APIs) dominates
much of the early drug development portfolio and poses a major challenge in …

Amorphous solid dispersions (ASDs) are among the most popular and widely studied
solubility enhancement techniques. Since their inception in the early 1960s, the formulation …

Amorphous solid dispersions (ASDs) are being used with increasing frequency for poorly
soluble pharmaceutical compounds in development. These systems consist of an …

A structured development approach is presented to guide the development of stable and
commercially viable polymer based amorphous formulations. The proposed approach …

Amorphous solid dispersions stabilized by one or more polymer (s) have been widely used
for delivering amorphous drugs with poor water solubilities, and they have gained great …