A structured development approach is presented to guide the development of stable and
commercially viable amorphous formulations. The proposed approach should not only …

The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …

Successful development of amorphous solid dispersion formulations depends on three
primary factors: active pharmaceutical ingredient properties, stabilizing polymer, and the …

Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

Solid dispersion (SD) system has been used as an effective formulation strategy to increase
in vitro and in vivo performances of poorly water-soluble drugs, such as …

Historically, amorphous solid dispersion technology with polymeric carriers has been
employed to stabilize high-energy amorphous phases of poorly water-soluble drug …

The use of amorphous solid dispersions (ASD) to overcome poor drug solubility has gained
interest in the pharmaceutical industry over the past decade. ASDs are challenging to …

It is well recognized that poor dissolution rate and solubility of drug candidates are key
limiting factors for oral bioavailability. While numerous technologies have been developed to …

The present work highlights the use of miniaturized approaches to screen and prioritize
development of solid dispersions that provide stabilization of the amorphous drug against …

Solid dispersion has emerged as a method of choice and has been extensively investigated
to ascertain the in vivo improved performance of many drug formulations. It generally …