The use of amorphous solid dispersions to improve the bioavailability of active ingredients
from the BCS II and IV classifications continues to gain interest in the pharmaceutical …

Drug and polymer mixing status in amorphous solid dispersions, an important aspect with
regard to the physical stability and in vivo performance of such systems, was evaluated in …

The study of amorphous solid dispersions (ASDs) is currently one of the most exciting areas
in pharmaceutics. Research has shown that ASDs offer unique advantages in improving the …

The major challenges in the formulation of amorphous solid dispersions (ASDs) using hot-
melt extrusion (HME) are the selection of an ideal polymeric carrier, optimization of HME …

Amorphous solid dispersion formulations (ASD) are increasingly being used as a
formulation strategy to improve bioavailability of poorly soluble drugs. One of the limitations …

Background: The current challenge in drug development lies in addressing the
physicochemical issues that lead to low drug effectiveness. Solubility, a crucial …

Abstract Forty-eight (48) drug products (DPs) containing amorphous solid dispersions
(ASDs) have been approved by the US Food and Drug Administration in the 12-year period …

Preparation of amorphous solid dispersions using polymers is a commonly used formulation
strategy for enhancing the solubility of poorly water-soluble drugs. However, often a single …

The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Amorphous solid dispersions (ASDs) have gained attention as a formulation strategy in
recent years, with the potential to improve the apparent solubility and, hence, the oral …