Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …

The toolbox of methods for generating amorphous solid dispersions, which are often critical
to achieving high kinetic solubility and bioavailability of drug molecules, continues to grow …

Co-precipitation is an emerging manufacturing strategy for amorphous solid dispersions
(ASDs). Herein, the interplay between processing conditions, surface composition, and …

For optimal bioperformance, the drug in an amorphous solid dispersion (ASD) should ideally
not undergo crystallization in the solid dosage form during storage or from the …

Amorphous solid dispersions (ASDs) can increase the bioavailability of drugs with poor
aqueous solubility. However, concentration-sustaining dispersion polymers (CSPs) …

Presently, a large number of drug molecules in development are BCS class II or IV
compounds with poor aqueous solubility. Various novel solubilization techniques have been …

Amorphous solid dispersions (ASDs) are an attractive option to improve the bioavailability of
poorly water-soluble compounds. However, the material attributes of ASDs can present …

A thorough understanding of effects of polymers on crystallization of amorphous drugs is
essential for rational design of robust amorphous solid dispersion (ASD), since …

Purpose Precipitation of amorphous solid dispersions has gained traction in the
pharmaceutical industry given its application to pharmaceuticals with varying …

The chemical structure of excipients molecularly mixed in an amorphous solid dispersion
(ASD) has a significant impact on properties of the ASD including dissolution behavior …