Identification of SARS‐CoV‐2 Papain‐like Protease (PLpro) Inhibitors Using Combined Computational Approach

M Sencanski, V Perovic, J Milicevic… - …, 2022 - Wiley Online Library
In the current pandemic, finding an effective drug to prevent or treat the infection is the
highest priority. A rapid and safe approach to counteract COVID‐19 is in silico drug …

In silico analysis of SARS-CoV-2 papain-like protease potential inhibitors

SA Elseginy, MM Anwar - RSC advances, 2021 - pubs.rsc.org
The emergent outbreak caused by severe acute respiratory syndrome coronavirus 2
continues spreading and causing huge social and economic disruption. Papain-like …

Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method

M Sencanski, V Perovic, SB Pajovic, M Adzic… - Molecules, 2020 - mdpi.com
The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a
high transmission rate with currently no drugs or vaccines approved. An alternative powerful …

In Silico and In Vitro Inhibition of SARS-CoV-2 PLpro with Gramicidin D

S Protić, N Kaličanin, M Sencanski… - International journal of …, 2023 - mdpi.com
Finding an effective drug to prevent or treat COVID-19 is of utmost importance in tcurrent
pandemic. Since developing a new treatment takes a significant amount of time, drug …

[HTML][HTML] Computer-aided drug design for the pain-like protease (PLpro) inhibitors against SARS-CoV-2

H Gao, R Dai, R Su - Biomedicine & Pharmacotherapy, 2023 - Elsevier
A new coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2), is a highly contagious virus and has caused a massive worldwide health crisis …

Step toward repurposing drug discovery for COVID‐19 therapeutics through in silico approach

BN Marak, J Dowarah, L Khiangte… - Drug Development …, 2021 - Wiley Online Library
The outbreak of SARS‐CoV‐2 has become a threat to global health and has led to a global
economic crisis. Although the researchers worldwide are putting tremendous effort toward …

In-silico approaches for identification of compounds inhibiting SARS-CoV-2 3CL protease

M Zeyaullah, N Khan, K Muzammil, AM AlShahrani… - PloS one, 2023 - journals.plos.org
The world has witnessed of many pandemic waves of SARS-CoV-2. However, the incidence
of SARS-CoV-2 infection has now declined but the novel variant and responsible cases has …

Discovery of potential SARS-CoV-2 papain-like protease natural inhibitors employing a multi-phase in silico approach

EB Elkaeed, AM Metwaly, MS Alesawy, AM Saleh… - Life, 2022 - mdpi.com
As an extension of our research against COVID-19, a multiphase in silico approach was
applied in the selection of the three most common inhibitors (Glycyrrhizoflavone (76) …

Combining computational and experimental evidence on the activity of antimalarial drugs on papain‐like protease of SARS‐CoV‐2: A repurposing study

G Ribaudo, X Yun, A Ongaro… - Chemical Biology & …, 2023 - Wiley Online Library
The development of inhibitors that target the papain‐like protease (PLpro) has the potential
to counteract the spread of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV …

Identification of Triazolopyrimidinyl Scaffold SARS-CoV-2 Papain-Like Protease (PLpro) Inhibitor

S Kralj, M Jukič, M Bahun, L Kranjc, A Kolarič… - Pharmaceutics, 2024 - mdpi.com
The global impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its
companion disease, COVID-19, has reminded us of the importance of basic coronaviral …