The innate immune system is a dynamic and complex network for recognizing and
responding to cellular insult or tissue damage after infection or injury. The primary effector …

The complementary actions of the innate and adaptive immune systems often provide
effective host defense against microbial pathogens and harmful environmental agents …

Maintenance of immune homeostasis is an intricate process wherein inflammasomes play a
pivotal role by contributing to innate and adaptive immune responses. Inflammasomes are …

Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Inflammasomes are supramolecular organizing centers that operate to drive interleukin-1 (IL-
1)-dependent inflammation. Depending on context, inflammatory caspases act upstream or …

The cells of the innate immune system mobilize a coordinated immune response towards
invading microbes and after disturbances in tissue homeostasis. These immune responses …

Inflammasomes, multiprotein platforms of caspase-1 activation, are assembled in response
to a number of exogenous and endogenous danger signals, leading to the production of pro …

Innate immune responses have the ability to both combat infectious microbes and drive
pathological inflammation. Inflammasome complexes are a central component of these …

Inflammasomes are key signalling platforms that detect pathogenic microorganisms and
sterile stressors, and that activate the highly pro-inflammatory cytokines interleukin-1β (IL …

Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …