Several approaches are currently being pursued in order to improve the efficacy of influenza
vaccines in elderly individuals and others who have impaired immune responses to …

Background Seasonal influenza epidemics are responsible for significant disease burden
each year, especially in adults over the age of 65. Only recently have there been vaccines …

A cluster-randomised controlled trial of antiviral treatment to control influenza outbreaks in
aged-care facilities (ACFs) provided an opportunity to assess VE in the frail, institutionalised …

Background New influenza vaccine formulations are designed to improve vaccine
effectiveness and protect those most vulnerable to infection. High dose trivalent inactivated …

Influenza is a leading cause of morbidity and mortality in elderly people. This prospective,
observed-blind, randomized, multicenter trial compares the immunogenicity and safety of …

Background Several aggregate data meta-analyses have provided estimates of the
effectiveness of influenza vaccination in community-dwelling elderly people. However, these …

Seasonal influenza disproportionately affects individuals aged 65 years or older, accounting
for 70% to 85% of deaths from the disease and 50% to 70% of hospitalizations. Vaccination …

Background The seasonal influenza vaccine is less effective in older people and a single
dose is unlikely to provide the year-round protection necessary for tropical climates which …

Objectives Summary evidence of influenza vaccine effectiveness (IVE) against hospitalized
influenza is lacking. We conducted a meta-analysis of studies reporting IVE against …

Background RIV4 and cell-culture based inactivated influenza vaccine (ccIIV4) have not
been compared to egg-based IIV4 in healthcare personnel, a population with frequent …