… structures with small molecule inhibitors bound in a surprising … SARS-CoV PLpro inhibitor
GRL-0617, and recapitulate how new GRL-0617 derivatives exploit different features of PLpro, …

… SARS-CoV-2 PLpro inhibition activity as the primary screening tool for the discovery of the
small molecule inhibitors, … four compounds that strongly inhibit SARS-CoV-2 PLpro. These are …

… -CoV-2 antivirals. Additionally, we show that the combined inhibition of Mpro and PLpro
is more effective in inhibiting SARS-CoV-2 and the delta variant. …

… SARS2 PLpro identified no compounds that inhibited PLpro … molecule SARS PLpro inhibitors
also target SARS2 PLpro, … excellent antiviral activity in a SARS-CoV-2 infection model. …

… again the challenge in developing potent PLpro inhibitors. … potent PLpro inhibitors would
require exploiting binding cooperativity to leverage multiple shallow binding sites on the PLpro …

… We additionally tested several kinase inhibitors and … 50 3.33 ± 0.06 μM) as PL pro inhibitors
for the first time. In some … this virus, or we have used Calu-3 cells infected with SARS-CoV-2…

… as potential SARS-CoV-2 PLpro inhibitors that we … PLpro inhibitor, showed antiviral action
against SARS-CoV-2. Quinine, proposed as PLpro inhibitor in this work, inhibited SARS-CoV-…

… 6 from promising SARS-CoV PLpro inhibitors 26,29 based … data of SARS-CoV-2 PLpro
support the claim that PLpro is a … structure of PLpro C111S in complex with the potent inhibitor …

… sheds light on SARS-CoV2 PLpro and its role in the pathogenesis of COVID-19 by characterizing
its deISGylation activity. It suggests that inhibition of PLpro would not only inhibits viral …

… and irreversible inhibitors with a high degree of selectivity for SARS PLpro variants versus
… of these inhibitors (VIR250 and VIR251) in complex with SARS-CoV-2-PLpro which reveals …