Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin

F Krammer, P Palese, J Steel - Influenza Pathogenesis and Control …, 2015 - Springer
… epitopes for neutralizing antibodies on the influenza virus hemagglutinin protein, which are
… targets of novel vaccine design. The aims of developing improved vaccines include eliciting …

The quest for a truly universal influenza vaccine

YH Jang, BL Seong - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
… a universal influenza vaccine (UIV) to provide broad and durable protection from influenza
… and cross-reactive T cells directed to influenza viral targets present a promising prospect for …

Options and obstacles for designing a universal influenza vaccine

YH Jang, BL Seong - Viruses, 2014 - mdpi.com
… This review summarizes recent advancements in the HA stalk-based universal influenza
vaccines, … future guidelines towards the design of a truly protective universal influenza vaccine. …

The challenges of creating a universal influenza vaccine

AY Egorov - Microbiology Independent Research Journal (MIR …, 2016 - cyberleninka.ru
influenza viruses of another subtype. In this regard, there is an urgent need for a more effective
universal influenza vaccine … , and is able to protect against influenza A and B viruses of all …

Immunodominance and antigenic variation of influenza virus hemagglutinin: implications for design of universal vaccine immunogens

SJ Zost, NC Wu, SE Hensley… - The Journal of infectious …, 2019 - academic.oup.com
… conserved among different influenza virus strains. Universal influenza vaccines are currently
… sites on influenza proteins where viral escape mutations can result in large fitness costs [1]. …

Targeting B cell responses in universal influenza vaccine design

K Kaur, M Sullivan, PC Wilson - Trends in immunology, 2011 - cell.com
influenza vaccines and towards a future with a pan-influenza vaccine capable of providing
universal … that will ultimately lead to the development of a viable universal influenza vaccine. …

Progress towards the development of a universal influenza vaccine

WC Wang, EE Sayedahmed, S Sambhara, SK Mittal - Viruses, 2022 - mdpi.com
… , ie, H1 vaccine protects against H5, H7... viruses). This review discusses … vaccine strategies
of universal influenza vaccine development, including the conserved antigens of influenza

Flu universal vaccines: new tricks on an old virus

R Du, Q Cui, L Rong - Virologica Sinica, 2021 - Springer
… of influenza viruses that can facilitate immunogen design and contribute to the development
of universal influenza vaccines. … immunological target for universal influenza vaccine design. …

Dynamic perspectives on the search for a universal influenza vaccine

CM Saad-Roy, AB McDermott… - The Journal of Infectious …, 2019 - academic.oup.com
universal influenza vaccine (UIV) could considerably alleviate the public health burden of
both seasonal and pandemic influenza… is a major focus on universal influenza vaccine (UIV) to …

Targeting antigens for universal influenza vaccine development

QT Nguyen, YK Choi - Viruses, 2021 - mdpi.com
… , an effective influenza vaccine is … universal influenza vaccines (UIVs) that are able to provide
at least 75% effectiveness against symptomatic disease caused by group 1 and 2 influenza