Cellular redox status has been considered as a focal point for the pathogenesis of multiple
disorders. High and persistent levels of free radicals kick off inflammation and associated …

Naphthoquinones may cause oxidative stress in exposed cells and, therefore, affect redox
signaling. Here, contributions of redox cycling and alkylating properties of quinones (both …

Naturally occurring naphthoquinones, usually in forms of botanical extracts, have been
implicated with human life since ancient time, far earlier than their isolation and identification …

Natural product derivatives are essential in searching for compounds with important
chemical, biological, and medical applications. Naphthoquinones are secondary …

Naphthoquinones have been investigated as potential therapeutic molecules for
neurodegenerative disorders, which is largely based on their anti-oxidative potential …

Various secondary metabolites from plants, bacteria and fungi are redox active and able to
modulate the intracellular redox equilibrium in living cells. Many of these compounds …

Cancer is a heterogeneous disease with high morbidity and mortality rate involving changes
in redox balance and deregulation of redox signalling. For decades, studies have involved …

Naphthoquinone derivatives have various pharmacological properties. Here, we describe
the synthesis of new 1, 4-naphthoquinone derivatives inspired by lawsone and β-lapachone …

Low levels of oxidative stress have been shown to activate Nrf-2, an important anti-
inflammatory transcription factor, by us and also by several other investigators. Earlier we …

Background: Naphthoquinones are natural pigments that are widely distributed in nature
and have important biological activities. Lawsone (2-hydroxy-1, 4-naphthoquinone) and its …