Redox homeostasis is frequently dysregulated in human disease, particularly cancer.
Recent and ongoing efforts seek to validate and extend this platform for the discovery …

The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the
rational design of new anticancer agents. In addition to their well characterized effects on …

The survival, functioning and proliferation of mammalian cells are highly dependent on the
cellular response and adaptation to changes in their redox environment. Cancer cells often …

Significance: Glutathione is the most abundant antioxidant molecule in living organisms and
has multiple functions. Intracellular glutathione homeostasis, through its synthesis …

Introduction The thioredoxin system is increasingly recognized as an important executor for
maintaining cell redox homeostasis and regulating multiple cell signaling pathways …

Reactive oxygen species (ROS) play a central role as second messengers in many signal
transduction pathways, where they can post-translationally modify proteins via the oxidation …

Redox dysregulation originating from metabolic alterations and dependence on mitogenic
and survival signaling through reactive oxygen species represents a specific vulnerability of …

Significance: There are a number of redox-active anticancer agents currently in
development based on the premise that altered redox homeostasis is necessary for cancer …

Glutathione (GSH) provides a major source of thiol homeostasis critical to the maintenance
of a reduced cellular environment that is conducive to cell survival. Mammals have …

Most cancer cells contain high levels of reactive oxygen species (ROS), which result in
higher expression levels of the glutathione and thioredoxin reductase systems. These …