Synthesis of newly functionalized 1, 4-naphthoquinone derivatives and their effects on wound healing in alloxan-induced diabetic mice

SH Cardoso, CR de Oliveira, AS Guimarães… - Chemico-Biological …, 2018 - Elsevier
Naphthoquinone derivatives have various pharmacological properties. Here, we describe
the synthesis of new 1, 4-naphthoquinone derivatives inspired by lawsone and β-lapachone …

[HTML][HTML] Current status of 1, 4-Naphthoquinones and their derivatives for wound healing

P Kumari, V Singh, V Kant, M Ahuja - European Journal of Medicinal …, 2024 - Elsevier
Cutaneous wounds are a major healthcare concern affecting millions of people as they fail
to heal properly and can result in life threatening conditions and high economic loss. Wound …

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol

EL Bonifazi, C Ríos-Luci, LG León, G Burton… - Bioorganic & medicinal …, 2010 - Elsevier
A series of 5-hydroxy-1, 4-naphthoquinones analogues was synthesized from juglone (6)
and their antiproliferative activity against a representative panel of six human solid tumor cell …

Synthesis and biological evaluation of new naphthoquinones derivatives

EM Ourhzif, C Decombat… - Current Organic …, 2020 - ingentaconnect.com
New substituted 1, 4-naphthoquinones have been prepared in good overall yields through
the naphthol route. The cytotoxicity of these compounds was tested in vitro on MCF-7 breast …

Synthesis and preliminary pharmacological evaluation of new (±) 1, 4-naphthoquinones structurally related to lapachol

AJM da Silva, CD Buarque, FV Brito, L Aurelian… - Bioorganic & medicinal …, 2002 - Elsevier
Seven new 1, 4-naphthoquinones structurally related to lapachol were synthesized from
lawsone and oxygenated arylmercurials. These compounds can also be seen as …

In vitro and in vivo wound healing-promoting activities of β-lapachone

HN Kung, MJ Yang, CF Chang… - American Journal of …, 2008 - journals.physiology.org
Impaired wound healing is a serious problem for diabetic patients. Wound healing is a
complex process that requires the cooperation of many cell types, including keratinocytes …

Synthesis of new 9-hydroxy-α-and 7-hydroxy-β-pyran naphthoquinones and cytotoxicity against cancer cell lines

DR da Rocha, ACG de Souza… - Organic & …, 2011 - pubs.rsc.org
A synthetic method to obtain α-and β-pyran naphthoquinones 10 and 11 with a hydroxyl
substituent on the aromatic ring was developed. Two series of α-and β-pyran …

Design, synthesis, biological evaluation, and antioxidant and cytotoxic activity of heteroatom-substituted 1, 4-naphtho-and benzoquinones

NG Deniz, C Ibis, Z Gokmen, M Stasevych… - Chemical and …, 2015 - jstage.jst.go.jp
Design, Synthesis, Biological Evaluation, and Antioxidant and Cytotoxic Activity of
Heteroatom-Substituted 1,4-Naphtho- and Benzoquinones Toggle navigation J-STAGE home …

[HTML][HTML] Synthesis, characterization and in-vitro evaluation of novel naphthoquinone derivatives and related imines: Identification of new anticancer leads

S Golmakaniyoon, VR Askari, K Abnous… - Iranian Journal of …, 2019 - ncbi.nlm.nih.gov
Abstract Quinones such as 1, 4-naphthoquinones are abundant in nature and
naphthoquinone based natural products are known to possess anticancer activity. This …

Antioxidant, antiproliferative, and acetylcholinesterase inhibition activity of amino alcohol derivatives from 1, 4-naphthoquinone

A Estolano-Cobián, E Noriega-Iribe… - Medicinal Chemistry …, 2020 - Springer
Natural and synthetic naphthoquinones have demonstrated numerous biological activities;
therefore, they provide an interesting scaffold for medicinal chemists in the search for new …