Isothiocyanates are phytochemicals with anti-cancer properties that include the ability to
trigger apoptosis. A substantial body of evidence suggests that reaction of the electrophilic …

The Prxs (peroxiredoxins) are a family of cysteine-dependent peroxidases that decompose
hydrogen peroxide. Prxs become hyperoxidized when a sulfenic acid formed during the …

Prxs (peroxiredoxins) are a family of proteins that are extremely effective at scavenging
peroxides. The Prxs exhibit a number of intriguing properties that distinguish them from …

Peroxiredoxins (Prxs) detoxify peroxides and modulate H 2 O 2-mediated cell signaling in
normal and numerous pathophysiological contexts. The typical 2-Cys subclass of Prxs …

Peroxiredoxins (Prxs) are a ubiquitous family of thiol peroxidases that protect cells from
peroxides and have a putative role in redox signaling. In this study, we investigated the …

Mitochondrial peroxiredoxin 3 (Prx 3) is rapidly oxidized in cells exposed to phenethyl
isothiocyanate (PEITC) and auranofin (AFN), but the mechanism of oxidation is unclear …

The proteins from the thioredoxin family are crucial actors in redox signaling and the cellular
response to oxidative stress. The major intracellular source for oxygen radicals are the …

It is hypothesized that activation of death receptors disrupts the redox homeostasis of cells
and that this contributes to the induction of apoptosis. The redox status of the peroxiredoxins …

The mitochondria are the major intracellular source of reactive oxygen species (ROS), which
are generated during cellular respiration. The role of peroxiredoxin (Prx) III, a 2-Cys Prx …

A dominant-negative, active-site mutant (C93S-Trx2) of mitochondrial thioredoxin-2 (Trx2)
was expressed in cells to study the function of the thioredoxin system in protection against …