Natural and synthetic isothiocyanates possess anticancer potential against liver and prostate cancer in vitro

E Crowley, NJ Rowan, D Faller, AM Friel - Anticancer Research, 2019 - ar.iiarjournals.org
Background/Aim: Isothiocyanates (ITCs) are phytochemicals with potential cancer-
preventative properties derived from the breakdown of glucosinolates that exist in …

Molecular targets of isothiocyanates in cancer: recent advances

P Gupta, B Kim, SH Kim… - Molecular nutrition & food …, 2014 - Wiley Online Library
Cancer is a multistep process resulting in uncontrolled cell division. It results from aberrant
signaling pathways that lead to uninhibited cell division and growth. Various recent …

Mechanisms of the anticancer effects of isothiocyanates

NM Fofaria, A Ranjan, SH Kim, SK Srivastava - The enzymes, 2015 - Elsevier
Cancer results from aberrant signaling pathways that result in uncontrolled cellular
proliferation. The epidemiological studies have shown a strong inverse correlation between …

Are isothiocyanates potential anti-cancer drugs?

X Wu, Q Zhou, K Xu - Acta Pharmacologica Sinica, 2009 - nature.com
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate
precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic …

Anticarcinogenic effects of isothiocyanates on hepatocellular carcinoma

Y Zhang, H Huang, L Jin, S Lin - International Journal of Molecular …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer,
accounting for about 90% of cases. Sorafenib, lenvatinib, and the combination of …

Dietary organic isothiocyanates are cytotoxic in human breast cancer MCF-7 and mammary epithelial MCF-12A cell lines

E Tseng, EAS Ramsay… - Experimental Biology and …, 2004 - journals.sagepub.com
Organic isothiocyanates (ITCs) are dietary components present in cruciferous vegetables.
The purpose of this investigation was to examine the cytotoxicity of 1-naphthyl …

Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy

G Na, C He, S Zhang, S Tian, Y Bao… - International Journal of …, 2023 - mdpi.com
Diet plays an important role in health. A high intake of plant chemicals such as
glucosinolates/isothiocyanates can promote optimal health and decrease the risk of cancer …

Vegetable-derived isothiocyanates: anti-proliferative activity and mechanism of action

Y Zhang, S Yao, J Li - Proceedings of the Nutrition Society, 2006 - cambridge.org
Many isothiocyanates (ITC), which are available to human subjects mainly through
consumption of cruciferous vegetables, demonstrate strong cancer-preventive activity in …

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G 2 /M arrest and inducing …

D Xiao, SK Srivastava, KL Lew, Y Zeng… - …, 2003 - academic.oup.com
Dietary isothiocyanates (ITCs) are highly effective in affording protection against chemically
induced cancers in laboratory animals. In the present study, we demonstrate that allyl …

[HTML][HTML] Perspective on dietary isothiocyanates in the prevention, development and treatment of cancer

H Yeger, RB Mokhtari - Journal of Cancer Metastasis and …, 2020 - oaepublish.com
Epidemiological evidence has highlighted the association of specific diets and a lower
incidence of cancer. Foremost, the Mediterranean diet provides high levels of polyphenolics …