Biological targets of isothiocyanates

KK Brown, MB Hampton - Biochimica et Biophysica Acta (BBA)-General …, 2011 - Elsevier
BACKGROUND: Isothiocyanates are phytochemicals with a broad array of effects in
biological systems. Bioactivity includes the stimulation of cellular antioxidant systems …

Natural isothiocyanates: genotoxic potential versus chemoprevention

C Fimognari, E Turrini, L Ferruzzi, M Lenzi… - … Research/Reviews in …, 2012 - Elsevier
Isothiocyanates, occurring in many dietary cruciferous vegetables, show interesting
chemopreventive activities against several chronic–degenerative diseases, including …

Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress

Y Zhang, J Li, L Tang - Free Radical Biology and Medicine, 2005 - Elsevier
Isothiocyanates (ITCs), a class of phytochemicals with promising cancer-preventive
potential, are double-edged swords in the modulation of cellular oxidative stress. While ITCs …

[HTML][HTML] Are isothiocyanates potential anti-cancer drugs?

X Wu, Q Zhou, K Xu - Acta Pharmacologica Sinica, 2009 - nature.com
Isothiocyanates are naturally occurring small molecules that are formed from glucosinolate
precursors of cruciferous vegetables. Many isothiocyanates, both natural and synthetic …

Proteins as binding targets of isothiocyanates in cancer prevention

L Mi, AJ Di Pasqua, FL Chung - Carcinogenesis, 2011 - academic.oup.com
Isothiocyanates are versatile cancer-preventive compounds. Evidence from animal studies
indicates that the anticarcinogenic activities of ITCs involve all the major stages of tumor …

Naturally occurring isothiocyanates exert anticancer effects by inhibiting deubiquitinating enzymes

AP Lawson, MJC Long, RT Coffey, Y Qian… - Cancer research, 2015 - AACR
The anticancer properties of cruciferous vegetables are well known and attributed to an
abundance of isothiocyanates such as benzyl isothiocyanate (BITC) and phenethyl …

[HTML][HTML] Dietary isothiocyanates: Novel insights into the potential for cancer prevention and therapy

G Na, C He, S Zhang, S Tian, Y Bao… - International Journal of …, 2023 - mdpi.com
Diet plays an important role in health. A high intake of plant chemicals such as
glucosinolates/isothiocyanates can promote optimal health and decrease the risk of cancer …

Isothiocyanates: a class of bioactive metabolites with chemopreventive potential

G Kumar, HS Tuli, S Mittal, JK Shandilya, A Tiwari… - Tumor Biology, 2015 - Springer
In recent years, growing interest has been focused on the field of chemoprevention using
natural therapies. The reason to turn toward “natural” remedies is associated with diverse …

Identification of potential protein targets of isothiocyanates by proteomics

L Mi, BL Hood, NA Stewart, Z Xiao… - Chemical research in …, 2011 - ACS Publications
Isothiocyanates (ITCs), such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN),
are effective cancer chemopreventive compounds. It is believed that the major mechanism …

Isothiocyanates as novel cytotoxic and cytostatic agents: molecular pathway on human transformed and non-transformed cells

C Fimognari, M Nüsse, F Berti, R Iori… - Biochemical …, 2004 - Elsevier
Cancer chemoprevention is a new approach in the management of cancer. Traditional
cytotoxic chemotherapeutic approaches cannot cure most advanced solid malignancies …