In vitro and in vivo wound healing-promoting activities of β-lapachone

HN Kung, MJ Yang, CF Chang… - American Journal of …, 2008 - journals.physiology.org
Impaired wound healing is a serious problem for diabetic patients. Wound healing is a
complex process that requires the cooperation of many cell types, including keratinocytes …

Induction of Egr-1 is associated with anti-metastatic and anti-invasive ability of β-lapachone in human hepatocarcinoma cells

SO Kim, JI Kwon, YK Jeong, GY Kim… - Bioscience …, 2007 - academic.oup.com
Abstract β-lapachone, a quinone compound obtained from the bark of the lapacho tree
(Tabebuia avellanedae), was reported to have anti-inflammatory and anti-cancer activities …

An evaluation on potential anti-inflammatory effects of β-lapachone

N Mokarizadeh, P Karimi, H Kazemzadeh… - International …, 2020 - Elsevier
Inflammation plays a significant role in the pathogenesis of chronic diseases. Inflammatory
diseases such as bacterial diseases, Alzheimer's disease, rheumatoid arthritis, multiple …

β-Lapachone suppresses the lung metastasis of melanoma via the MAPK signaling pathway

JY Kee, YH Han, DS Kim, JG Mun, SH Park, HS So… - PLoS …, 2017 - journals.plos.org
β-Lapachone is a natural quinone compound from Lapacho trees, which has various
pharmacological effects such as anti-bacterial, anti-fungal, anti-viral, and anti-inflammatory …

Involvement of NO/cGMP signaling in the apoptotic and anti‐angiogenic effects of β‐lapachone on endothelial cells in vitro

HN Kung, CL Chien, GY Chau, MJ Don… - Journal of Cellular …, 2007 - Wiley Online Library
Neovascularization is an essential process in tumor development, it is conceivable that anti‐
angiogenic treatment may block tumor growth. In angiogenesis, nitric oxide (NO) is an …

β-Lapachone inhibits lung metastasis of colorectal cancer by inducing apoptosis of CT26 cells

JY Kee, YH Han, J Park, DS Kim… - Integrative cancer …, 2017 - journals.sagepub.com
Background: β-Lapachone is a quinone-containing compound found in red lapacho
(Tabebuia impetiginosa, syn. T avellanedae) trees. Lapacho has been used in traditional …

Down-regulation of cyclooxygenase-2 and telomerase activity by β-lapachone in human prostate carcinoma cells

JH Lee, JH Cheong, YM Park, YH Choi - Pharmacological Research, 2005 - Elsevier
β-Lapachone, the product of a tree Tabebuia avellanedae from South America, is known to
exhibit various pharmacologic properties, the mechanisms of which are poorly understood …

Accelerative Wound-Healing Effect of Aqueous Anthocephalus Cadamba Leaf Extract in a Diabetic Rat Model

S Ali, S Ishteyaque, F Khan, P Singh… - … Journal of Lower …, 2023 - journals.sagepub.com
Impaired wound healing is a major concern in diabetic patients due to unregulated chronic
hyperglycemia which further may lead to ulcer, gangrene, and its complications. The present …

β-lapachone suppresses the proliferation of human malignant melanoma cells by targeting specificity protein 1

W Bang, YJ Jeon, JH Cho, RH Lee… - Oncology …, 2016 - spandidos-publications.com
Abstract β-lapachone (β-lap), a novel natural quinone derived from the bark of the Pink
trumpet tree (Tabebuia avellanedae) has been demonstrated to have anticancer activity. In …

β-Lapachone and its iodine derivatives cause cell cycle arrest at G2/M phase and reactive oxygen species-mediated apoptosis in human oral squamous cell …

RB Dias, TBS de Araújo, RD de Freitas… - Free Radical Biology …, 2018 - Elsevier
Abstract β-Lapachone is a natural naphthoquinone originally obtained from the bark of the
purple Ipe (Tabebuia avellanedae Lor, Bignoniaceae) and its therapeutic potential in human …