Cytotoxicity of 1, 4-naphthoquinones has been attributed to intracellular reactive oxygen
species (ROS) generation through one-electron-reductase-mediated redox cycling and to …

Experiments using purified recombinant human NAD (P) H: quinone oxidoreductase 1
(NQO1) revealed that the auto-oxidation of fully reduced protein resulted in a 1: 1 …

The toxicity of quinones is believed to be mediated via redox cycling involving formation of
semiquinone radicals which autoxidize to form active oxygen species. However, when the …

Quinones are believed to be toxic by a mechanism involving redox cycling and oxidative
stress. In this study, we have used 2, 3-dimethoxy-1, 4-naphthoquinone (2, 3-diOMe-1, 4 …

Nitroxide free radicals have been shown to be potent antioxidants in a variety of
experimental models using diverse means of insults. Among other insults, nitroxides have …

Quinones may be toxic by a number of mechanisms, including oxidative stress caused by
redox cycling and arylation. This study has compared the cytotoxicity of four quinones, with …

NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic flavoprotein that utilizes NRH as
electron donor. The present studies investigate the role of NQO2 in metabolic detoxification …

Quinones represent a class of toxicological intermediates, which can create a variety of
hazardous effects in vivo including, acute cytotoxicity, immunotoxicity, and carcinogenesis …

NAD (P) H: quinone oxidoreductase 1 (NQO1) has often been suggested to be involved in
cancer prevention by means of detoxification of electrophilic quinones. In the present study …

Quinones are a group of highly reactive organic chemical species that interact with
biological systems to promote inflammatory, anti-inflammatory, and anticancer actions and to …