Seven new 1, 4-naphthoquinones structurally related to lapachol were synthesized from
lawsone and oxygenated arylmercurials. These compounds can also be seen as …

Ozonolysis of lapachol (1), resulting in an unusual formation of a potent antitumor agent 2-
acetylfuranonaphthoquinone (3) along with the expected aldehyde 6, is described. The …

A series of 5-hydroxy-1, 4-naphthoquinones analogues was synthesized from juglone (6)
and their antiproliferative activity against a representative panel of six human solid tumor cell …

This review involves the chemistry and biochemistry of lapachol, β-lapachone and lawsone,
examples of bioactive natural products that still being under biological evaluation and …

Several 3-arylamino and 3-alkoxy-nor-β-lapachone derivatives were synthesized in
moderate to high yields and found to be highly potent against cancer cells SF295 (central …

Naphthoquinones have been found to have a wide range of biological activities, including
cytotoxicity to cancer cells. The secondary metabolites lapachol, α-and β-lapachone and a …

A series of 17 selected natural and semisynthetic 1, 4-naphthoquinones were synthesized,
and their growth inhibitory activity was evaluated in vitro. The compounds were tested on six …

A synthetic method to obtain α-and β-pyran naphthoquinones 10 and 11 with a hydroxyl
substituent on the aromatic ring was developed. Two series of α-and β-pyran …

The biological activities of the naphthoquinones lapachol, extracted from trees of the genus
Tabebuia and its cyclization products αand β-lapachone, have been intensively studied …

3, 4-Dihydro-2, 2-dimethyl-2 H-naphtho [1, 2-b] pyran-5, 6-dione (ARQ 501) is a fully
synthetic version of the natural product β-lapachone, which has been isolated from the …